cosyntropin (Cortrosyn)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jerry R. Balentine, DO, FACEP
    Jerry R. Balentine, DO, FACEP

    Jerry R. Balentine, DO, FACEP

    Dr. Balentine received his undergraduate degree from McDaniel College in Westminster, Maryland. He attended medical school at the Philadelphia College of Osteopathic Medicine graduating in1983. He completed his internship at St. Joseph's Hospital in Philadelphia and his Emergency Medicine residency at Lincoln Medical and Mental Health Center in the Bronx, where he served as chief resident.

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What is cosyntropin-injectable, and how does it work (mechanism of action)?

: Cosyntropin is a manufactured version of the body's natural adrenocorticotropin hormone (ACTH). ACTH is produced by the pituitary gland in the brain. It stimulates the adrenal gland to release steroids including hydrocortisone and cortisone, androgens, as well as aldosterone. Cosyntropin has the same activity as ACTH. The FDA approved Cosyntropin in April 1970.

What brand names are available for cosyntropin-injectable?

Cortrosyn

Is cosyntropin-injectable available as a generic drug?

GENERIC AVAILABLE: Yes

Do I need a prescription for cosyntropin-injectable?

Yes

What are the side effects of cosyntropin-injectable?

Adverse effects associated with the use of cosyntropin include slowed heart rate, high blood pressure, edema (fluid buildup) in limbs, and rapid heartbeat. Other adverse effects include rash as well as redness at the injection site. Side effects associated with corticosteroid use are also commonly reported with cosyntropin use. There have been rare reports of anaphylactic reactions.

What is the dosage for cosyntropin-injectable?

The initial dose for adults is based on what the drug is being used for and whether it is being given intravenously or intramuscularly. For example, the intravenous dose in diagnosing adrenocortical insufficiency is 0.25 mg. Initial doses of 1 mg intramuscularly may be used when transferring from corticosteroids.

Which drugs or supplements interact with cosyntropin-injectable?

: Cosyntropin may increase the electrolyte loss during diuretic therapy.

Is cosyntropin-injectable safe to take if I'm pregnant or breastfeeding?

It is unknown whether cosyntropin is excreted in breast milk and, therefore, should be used cautiously by mothers who are nursing.

What else should I know about cosyntropin-injectable?

What preparations of cosyntropin-injectable are available?

Powder (with and without preservatives) 0.25 mg; Solution: 0.25 mg/mL in 1 mL vial

How should I keep cosyntropin-injectable stored?

Cosyntropin powder should be stored at room temperature between 15 C to 30 C (59 F to 86 F). Cosyntropin solution and suspension should be stored under refrigeration between 2 C to 8 C (36 F to 46 F) and protected from light and freezing. Infusions are stable for 12 hours at room temperature.

Medically reviewed by John Cunha, DO

REFERENCE: FDA Prescribing Information.

Last Editorial Review: 8/7/2017

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Reviewed on 8/7/2017
References
Medically reviewed by John Cunha, DO

REFERENCE: FDA Prescribing Information.

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