Corticosteroids (Systemic, Oral and Injectable) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Are there any differences among the different types of systemic corticosteroids?

Corticosteroids differ in their relative amount of anti-inflammatory and mineralocorticoid potency and they are used according to these effects. Among the systemic (oral and injectable) corticosteroids, fludrocortisone (Florinef) has the most significant mineralocorticoid (salt retaining) actions and is best used for this effect despite it's strong anti-inflammatory action.

Other systemically available corticosteroids have mostly glucocorticoid effects, and are used for their anti-inflammatory activities. Examples of these include the naturally occurring hydrocortisone (Cortef) and cortisone, and the synthetic corticosteroids including:

  • bethamethasone (Celestone)
  • prednisone (Prednisone Intensol)
  • prednisolone (Orapred, Prelone)
  • triamcinolone (Aristospan Intra-Articular, Aristospan Intralesional, Kenalog)
  • methylprednisolone((Medrol, Depo-Medrol, Solu-Medrol)
  • dexamethasone (Dexamethasone Intensol, DexPak 10 Day, DexPak 13 Day, DexPak 6 Day).

Among all glucocorticoids, prednisone is not effective in the body unless it is converted to prednisolone by enzymes in the liver. For this reason prednisone may not be very effective in people with liver disease because of a reduction in their ability to convert prednisone to prednisolone.

What are the side effects of systemic corticosteroids?

Corticosteroids have many side effects that can be mild or serious. These side effects are more apparent when corticosteroids are used at higher doses or for extended periods of time. This section lists only some of these side effects of corticosteroids.

Corticosteroids can:

Medically Reviewed by a Doctor on 4/15/2014

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Finder Tool

Need help identifying pills and medications?
Use the pill identifier tool on RxList.

Back to Medications Index