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Penicillamine (Cuprimine, Depen)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.
Penicillamine is used for Wilson's disease and rheumatoid arthritis. Copper might decrease how much penicillamine your body absorbs and decrease the effectiveness of penicillamine.
For children, a Recommended Dietary Allowance (RDA) of copper has been set: 1 to 3 years, 340 mcg/day; 4 to 8 years, 440 mcg/day; 9 to 13, 700 mcg/day; 14 to 18 years, 890 mcg/day.
For men and women age 19 years and older, the RDA of copper is 900 mcg/day.
For pregnancy, the RDA is 1000 mcg/day, and breast feeding 1300 mcg/day for women of all ages.
The Tolerable Upper Intake Level (UL), the maximum amount for which no harmful effect is expected, has been established for children and adults. The ULs for copper are: children 1 to 3 years, 1 mg/day; 4 to 8 years, 3 mg/day; 9 to 13 years, 5 mg/day; 14 to 18 years (including pregnancy and lactation) 8 mg/day; adults age 19 and older (including breast feeding), 10 mg/day; pregnancy age 19 and older, 8 mg/day.
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.