conjugated estrogens vaginal cream, Premarin Vaginal Cream (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

PRESCRIBED FOR: Premarin vaginal cream is used for the relief of vaginal symptoms in postmenopausal women who have developed uncomfortable vaginal dryness, inflammation, or painful intercourse due to atrophy of the vagina and/or vulvae.

SIDE EFFECTS: Among the most common endocrine side effects are:

  • breakthrough vaginal bleeding
  • spotting,
  • loss of periods,
  • excessively prolonged periods,
  • breast pain or
  • breast enlargement, and
  • changes in sexuality (increases or decreases in libido).

Other important side effects include:

Melasma--tan or brown patches-- may develop on the forehead, cheeks, or temples. These may persist even after the estrogen is stopped.

Conjugated estrogens may increase the curvature of the cornea, and patients with contact lenses may develop intolerance to their lenses.

Blood clots are an occasional, serious side effect of estrogen therapy and are dose-related. (The higher the dose of estrogen, the greater the risk of blood clots.) Cigarette smokers are at a higher risk than non-smokers for blood clots, and patients requiring estrogens should be encouraged to quit smoking.

Medically Reviewed by a Doctor on 12/24/2014

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