conjugated estrogens vaginal cream, Premarin Vaginal Cream

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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GENERIC NAME: conjugated estrogens vaginal cream

BRAND NAME: Premarin Vaginal Cream

DRUG CLASS AND MECHANISM: Estrogens are one of the two major classes of female hormones. (Progestins comprise the second major class). Estrogens are used primarily to treat the symptoms of menopause and states in which there is a deficiency of estrogen, for example, among women who have had their estrogen-producing ovaries removed. Conjugated estrogens are a mixture of several different estrogens (estrogen salts) that are derived from natural sources and blended to approximate the composition of estrogens in the urine of pregnant horses. The main components are sodium estrone sulphate and sodium equilin sulfate. Estrogens have widespread effects on tissues in the body. Estrogens cause growth and development of the female sexual organs and maintain female sexual characteristics such as the growth of underarm and pubic hair, body contours, and skeleton. Estrogens also increase secretions from the cervix and growth of the inner lining of the uterus (endometrium). Conjugated estrogens were first approved by the FDA in 1938.

PRESCRIBED FOR: Premarin vaginal cream is used for the relief of vaginal symptoms in postmenopausal women who have developed uncomfortable vaginal dryness, inflammation, or painful intercourse due to atrophy of the vagina and/or vulvae.

SIDE EFFECTS: Among the most common endocrine side effects are:

  • breakthrough vaginal bleeding
  • spotting,
  • loss of periods,
  • excessively prolonged periods,
  • breast pain or
  • breast enlargement, and
  • changes in sexuality (increases or decreases in libido).
Medically Reviewed by a Doctor on 12/24/2014

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