Blood: The familiar red fluid in the body that contains white and red blood cells, platelets, proteins, and other elements. The blood is transported throughout the body by the circulatory system. Blood functions in two directions: arterial and venous. Arterial blood is the means by which oxygen and nutrients are transported to tissues while venous blood is the means by which carbon dioxide and metabolic by-products are transported to the lungs and kidneys, respectively, for removal from the body.
Blood count: The calculated number of white or red blood cells (WBCs or RBCs) in a cubic millimeter of blood.
Bone: Bone is the substance that forms the skeleton of the body. It is composed chiefly of calcium phosphate and calcium carbonate . It also serves as a storage area for calcium, playing a large role in calcium balance in the blood.
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Bone marrow: The soft blood-forming tissue that fills the cavities of bones and contains fat and immature and mature blood cells, including white blood cells, red blood cells, and platelets. Diseases or drugs that affect the bone marrow can affect the total counts of these cells.
CBC: A commonly used abbreviation in medicine that stands for complete blood count , a set values of the cellular (formed elements) of blood. These measurements are generally determined by specially designed machines that analyze the different components of blood in less than a minute.
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Cell: The basic structural and functional unit in people and all living things. Each cell is a small container of chemicals and water wrapped in a membrane .
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Complete blood count : A set values of the cellular (formed elements) of blood. These measurements are generally determined by specially designed machines that analyze the different components of blood in less than a minute.
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Cytoplasm: All of the substance of a cell outside of the nucleus. The cytoplasm contains a number of different types organelles such as the mitochondria.
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Erythrocyte: A cell that contains hemoglobin and can carry oxygen to the body. Also called a red blood cell (RBC). The reddish color is due to the hemoglobin. Erythrocytes are biconcave in shape, which increases the cell's surface area and facilitates the diffusion of oxygen and carbon dioxide. This shape is maintained by a cytoskeleton composed of several proteins. Erythrocytes are very flexible and change shape when flowing through capillaries. Immature erythrocytes, called reticulocytes, normally account for 1-2 percent of red cells in the blood.
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Hematocrit: The proportion of the blood that consists of packed red blood cells . The hematocrit is expressed as a percentage by volume. The red cells are packed by centrifugation.
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Hemoglobin: The oxygen-carrying pigment and predominant protein in the red blood cells . Hemoglobin forms an unstable, reversible bond with oxygen. In its oxygenated state it is called oxyhemoglobin and is bright red. In the reduced state it is called deoxyhemoglobin and is purple-blue.
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Indicate: In medicine, to make a treatment or procedure advisable because of a particular condition or circumstance. For example, certain medications are indicated for the treatment of hypertension during pregnancy while others are contraindicated.
Leukocyte count: A white blood cell (WBC) count.
Liter: A metric measure of capacity that, by definition, is equal to the volume of a kilogram of water at 4 degrees centigrade and at standard atmospheric pressure of 760 millimeters of mercury. - Metric equivalents -- There are 1000 cubic centimeters or 1 cubic decimeter in 1 liter.
- U.S. equivalent -- A liter is a little more than a quart (1.057 U.S. liquid quarts).
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Marrow: The bone marrow.
MCH: Abbreviation for mean cell hemoglobin , which is the average amount of hemoglobin in the average red cell. The MCH is a calculated value derived from the measurement of hemoglobin and the red cell count. (The hemoglobin value is the amount of hemoglobin in a volume of blood while the red cell count is the number of red blood cells in a volume of blood.) The normal range for the MCH is 27 - 32 picograms. It is a standard part of the complete blood count .
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MCHC: Abbreviation for mean cell hemoglobin concentration, which is the average concentration of hemoglobin in a given volume of blood. The MCHC is a calculated value derived from the measurement of hemoglobin and the hematocrit . (The hemoglobin value is the amount of hemoglobin in a volume of blood while the hematocrit is the ratio of the volume of red cells to the volume of whole blood.) The normal range for the MCHC is 32 - 36%. The MCHC is a standard part of the complete blood count .
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MCV: Abbreviation for mean cell volume, the average volume of a red blood cell. This is a calculated value derived from the hematocrit and the red cell count (The hematocrit is the ratio of the volume of red cells to the volume of whole blood while the red cell count is the number of red blood cells in a volume of blood). The normal range for the MVC is 86 - 98 femtoliters. The MCV is a standard part of the complete blood count (CBC).
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Mean cell hemoglobin : The average amount of hemoglobin in the average red cell. The mean cell hemoglobin (MCH) is a calculated value derived from the measurement of hemoglobin and the red cell count. (The hemoglobin value is the amount of hemoglobin in a volume of blood while the red cell count is the number of red blood cells in a volume of blood.) The normal range for the MCH is 27 - 32 picograms. It is a standard part of the complete blood count .
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Mean cell volume : A standard part of the complete blood count , the mean cell volume ( MCV ) is the average volume of a red blood cell . This is a calculated value derived from the hematocrit and the red cell count (The hematocrit is the ratio of the volume of red cells to the volume of whole blood while the red cell count is the number of red blood cells in a volume of blood). The normal range for the mean cell volume is 86 - 98 femtoliters.
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Megakaryocyte: A giant cell in the bone marrow that is the ancestor of blood platelets.
Molecule: The smallest unit of a substance that can exist alone and retain the character of that substance.
Normal range: By convention, the normal range for whatever (a particular test, condition, symptom, behavior, etc.) is set to cover ninety-five percent (95%) of all values from the general population. Five percent (5%) of results consequently fall outside the normal range. Values that prove normal can therefore sometimes be outside the normal range.
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Oxygen: A colorless, odorless and tasteless gas that makes up about 20% of the air we breathe (and at least half the weight of the entire solid crust of the earth) and which combines with most of the other elements to form oxides. Oxygen is essential to human, animal and plant life.
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Platelet: An irregular, disc-shaped element in the blood that assists in blood clotting. During normal blood clotting, the platelets clump together (aggregate). Although platelets are often classed as blood cells, they are actually fragments of large bone marrow cells called megakaryocytes.
Platelet count: The calculated number of platelets in a volume of blood, usually expressed as platelets per cubic millimeter (cmm) of whole blood. Platelets are the smallest cell-like structures in the blood and are important for blood clotting and plugging damaged blood vessels. Platelet counts are usually done by laboratory machines that also count other blood elements such as the white and red cells. They can also be counted by use of a microscope. Normal platelet counts are in the range of 150,000 to 400,000 per microliter (or 150 - 400 x 109 per liter). These values many vary slightly between different laboratories.
Protein: A large molecule composed of one or more chains of amino acids in a specific order determined by the base sequence of nucleotides in the DNA coding for the protein.
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Range: In medicine and statistics, the difference between the lowest and highest numerical values. For example, if five premature infants are born weighing two, three, four, four, and five pounds respectively, the range of their birth weights is two to five pounds.
RBC: Short for red blood cells, the cells that carry oxygen and carbon dioxide through the blood. This rather remarkable feat is thanks to hemoglobin , the pigment that makes red cells (and blood) look red. The red blood cells are also known as red corpuscles or erythrocytes (literally, red hollow vessels).
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Red blood cells: The blood cells that carry oxygen. Red cells contain hemoglobin and it is the hemoglobin which permits them to transport oxygen (and carbon dioxide). Hemoglobin, aside from being a transport molecule, is a pigment. It gives the cells their red color (and their name).
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Red cell count: The number of red blood cells (RBCs) in a volume of blood. The normal range varies slightly between laboratories but is generally between 4.2 - 5.9 million cells/cmm. This can also be referred to as the erythrocyte count and can be expressed in international units as 4.2 - 5.9 x 1012 cells per liter.
Red cell distribution width: A measurement of the variability of red blood cell size. Higher numbers indicate greater variation in size. The normal range for the red cell distribution width (RDW) is 11 - 15. The RDW is a standard part of the complete blood count .
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Red cells: Short for red blood cells, the oxygen/carbon dioxide carrying cells in blood. Also known acronymically as RBC's, red corpuscles or erythrocytes (literally, red hollow vessels).
Vital: Necessary to maintain life. Breathing is a vital function.
WBC: Commonly used abbreviation for a white blood cell.
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White blood cell: One of the cells the body makes to help fight infections. There are several types of white blood cells ( leukocytes ). The two most common types are the lymphocytes and neutrophils (also called polymorphonuclear leukocytes, PMNs, or "polys").
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White blood cell count (leukocyte count): The number of white blood cells (WBCs) in the blood. The WBC is usually measured as part of the CBC ( complete blood count ). White blood cells are the infection-fighting cells in the blood and are distinct from the red (oxygen-carrying) blood cells known as erythrocytes. There are different types of white blood cells, including neutrophils (polymorphonuclear leukocytes ; PMNs), band cells (slightly immature neutrophils), T-type lymphocytes (T cells), B-type lymphocytes (B cells), monocytes, eosinophils, and basophils. All the types of white blood cells are reflected in the white blood cell count. The normal range for the white blood cell count varies between laboratories but is usually between 4,300 and 10,800 cells per cubic millimeter of blood. This can also be referred to as the leukocyte count and can be expressed in international units as 4.3 - 10.8 x 109 cells per liter.
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