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November 21, 2009
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 Complete Blood Count Main Article |  Glossary |  Complete Blood Count Index 

Complete Blood Count (CBC) Glossary of Terms

The following are health and medical definitions of terms that appear in the Complete Blood Count (CBC) article.

Analysis: A psychology term for processes used to gain understanding of complex emotional or behavioral issues.
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Anemia: The condition of having less than the normal number of red blood cells or less than the normal quantity of hemoglobin in the blood. The oxygen-carrying capacity of the blood is, therefore, decreased.
See the entire definition of Anemia

Blood count: The calculated number of white or red blood cells (WBCs or RBCs) in a cubic millimeter of blood.

Bone marrow: The soft blood-forming tissue that fills the cavities of bones and contains fat and immature and mature blood cells, including white blood cells, red blood cells, and platelets. Diseases or drugs that affect the bone marrow can affect the total counts of these cells.

CBC: A commonly used abbreviation in medicine that stands for complete blood count , a set values of the cellular (formed elements) of blood. These measurements are generally determined by specially designed machines that analyze the different components of blood in less than a minute.
See the entire definition of CBC

Cell: The basic structural and functional unit in people and all living things. Each cell is a small container of chemicals and water wrapped in a membrane .
See the entire definition of Cell

Chemotherapy : 1. In the original sense, a chemical that binds to and specifically kills microbes or tumor cells. The term chemotherapy was coined in this regard by Paul Ehrlich (1854-1915).
2. In oncology, drug therapy for cancer. Also called "chemo" for short.
See the entire definition of Chemotherapy

Circulation: The movement of fluid in a regular or circuitous course. Although the noun "circulation" does not necessarily refer to the circulation of the blood, for all practical purposes today it does. Heart failure is an example of a problem with the circulation.

Complete blood count : A set values of the cellular (formed elements) of blood. These measurements are generally determined by specially designed machines that analyze the different components of blood in less than a minute.
See the entire definition of Complete blood count

Cytoplasm: All of the substance of a cell outside of the nucleus. The cytoplasm contains a number of different types organelles such as the mitochondria.
See the entire definition of Cytoplasm

Erythrocyte: A cell that contains hemoglobin and can carry oxygen to the body. Also called a red blood cell (RBC). The reddish color is due to the hemoglobin. Erythrocytes are biconcave in shape, which increases the cell's surface area and facilitates the diffusion of oxygen and carbon dioxide. This shape is maintained by a cytoskeleton composed of several proteins. Erythrocytes are very flexible and change shape when flowing through capillaries. Immature erythrocytes, called reticulocytes, normally account for 1-2 percent of red cells in the blood.
See the entire definition of Erythrocyte

Essential: 1. Something that cannot be done without.
2. Required in the diet, because the body cannot make it. As in an essential amino acid or an essential fatty acid.
3. Idiopathic. As in essential hypertension. "Essential" is a hallowed term meaning "We don't know the cause."

Hematocrit: The proportion of the blood that consists of packed red blood cells . The hematocrit is expressed as a percentage by volume. The red cells are packed by centrifugation.
See the entire definition of Hematocrit

Hemoglobin: The oxygen-carrying pigment and predominant protein in the red blood cells . Hemoglobin forms an unstable, reversible bond with oxygen. In its oxygenated state it is called oxyhemoglobin and is bright red. In the reduced state it is called deoxyhemoglobin and is purple-blue.
See the entire definition of Hemoglobin

Hypoxia: A subnormal concentration of oxygen. By contrast with normoxia (normal oxygen) and anoxia (the absence or near absence of oxygen). From hyp– (below) + -ox- (oxygen) + –ia.

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Immune: Protected against infection. The Latin immunis means free, exempt.

Immune system: A complex system that is responsible for distinguishing us from everything foreign to us, and for protecting us against infections and foreign substances. The immune system works to seek and kill invaders.
See the entire definition of Immune system

Indicate: In medicine, to make a treatment or procedure advisable because of a particular condition or circumstance. For example, certain medications are indicated for the treatment of hypertension during pregnancy while others are contraindicated.

Infection: The growth of a parasitic organism within the body. (A parasitic organism is one that lives on or in another organism and draws its nourishment therefrom.) A person with an infection has another organism (a "germ") growing within him, drawing its nourishment from the person.
See the entire definition of Infection

Inflammation: A basic way in which the body reacts to infection , irritation or other injury, the key feature being redness, warmth, swelling and pain . Inflammation is now recognized as a type of nonspecific immune response .
See the entire definition of Inflammation

Laboratory: A place for doing tests and research procedures and preparing chemicals, etc. Although "laboratory" looks very like the Latin "laboratorium" (a place to labor, a work place), the word "laboratory" came from the Latin "elaborare" (to work out, as a problem, and with great pains), as evidenced by the Old English spelling "elaboratory" designating "a place where learned effort was applied to the solution of scientific problems."
See the entire definition of Laboratory

Leukocyte count: A white blood cell (WBC) count.

Leukocytosis: Increase in the number of white blood cells.

Leukopenia: Lower than the normal amount of white blood cells.

Liter: A metric measure of capacity that, by definition, is equal to the volume of a kilogram of water at 4 degrees centigrade and at standard atmospheric pressure of 760 millimeters of mercury.

  • Metric equivalents -- There are 1000 cubic centimeters or 1 cubic decimeter in 1 liter.
  • U.S. equivalent -- A liter is a little more than a quart (1.057 U.S. liquid quarts).

See the entire definition of Liter

Malignancy: A tumor that is malignant, that is cancerous, that can invade and destroy nearby tissue, and that may spread (metastasize) to other parts of the body.

Marrow: The bone marrow.

MCH: Abbreviation for mean cell hemoglobin , which is the average amount of hemoglobin in the average red cell. The MCH is a calculated value derived from the measurement of hemoglobin and the red cell count. (The hemoglobin value is the amount of hemoglobin in a volume of blood while the red cell count is the number of red blood cells in a volume of blood.) The normal range for the MCH is 27 - 32 picograms. It is a standard part of the complete blood count .
See the entire definition of MCH

MCHC: Abbreviation for mean cell hemoglobin concentration, which is the average concentration of hemoglobin in a given volume of blood. The MCHC is a calculated value derived from the measurement of hemoglobin and the hematocrit . (The hemoglobin value is the amount of hemoglobin in a volume of blood while the hematocrit is the ratio of the volume of red cells to the volume of whole blood.) The normal range for the MCHC is 32 - 36%. The MCHC is a standard part of the complete blood count .
See the entire definition of MCHC

MCV: Abbreviation for mean cell volume, the average volume of a red blood cell. This is a calculated value derived from the hematocrit and the red cell count (The hematocrit is the ratio of the volume of red cells to the volume of whole blood while the red cell count is the number of red blood cells in a volume of blood). The normal range for the MVC is 86 - 98 femtoliters. The MCV is a standard part of the complete blood count (CBC).
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Megakaryocyte: A giant cell in the bone marrow that is the ancestor of blood platelets.

Microscope: An optical instrument that augments the power of the eye to see small objects. The name microscope was coined by Johannes Faber (1574-1629) who in 1628 borrowed from the Greek to combined micro-, small with skopein, to view. Although the first microscopes were simple microscopes, most (if not all) optical microscopes today are compound microscopes.

Molecule: The smallest unit of a substance that can exist alone and retain the character of that substance.

MPH: Master of Public Health (a master's degree in this field of medicine).

Normal range: By convention, the normal range for whatever (a particular test, condition, symptom, behavior, etc.) is set to cover ninety-five percent (95%) of all values from the general population. Five percent (5%) of results consequently fall outside the normal range. Values that prove normal can therefore sometimes be outside the normal range.
See the entire definition of Normal range

Nucleus: 1) In cell biology, the structure that houses the chromosomes. 2) In neuroanatomy, a group of nerve cells.

Oxygen: A colorless, odorless and tasteless gas that makes up about 20% of the air we breathe (and at least half the weight of the entire solid crust of the earth) and which combines with most of the other elements to form oxides. Oxygen is essential to human, animal and plant life.
See the entire definition of Oxygen

Platelet: An irregular, disc-shaped element in the blood that assists in blood clotting. During normal blood clotting, the platelets clump together (aggregate). Although platelets are often classed as blood cells, they are actually fragments of large bone marrow cells called megakaryocytes.

Platelet count: The calculated number of platelets in a volume of blood, usually expressed as platelets per cubic millimeter (cmm) of whole blood. Platelets are the smallest cell-like structures in the blood and are important for blood clotting and plugging damaged blood vessels. Platelet counts are usually done by laboratory machines that also count other blood elements such as the white and red cells. They can also be counted by use of a microscope. Normal platelet counts are in the range of 150,000 to 400,000 per microliter (or 150 - 400 x 109 per liter). These values many vary slightly between different laboratories.

Protein: A large molecule composed of one or more chains of amino acids in a specific order determined by the base sequence of nucleotides in the DNA coding for the protein.
See the entire definition of Protein

RBC: Short for red blood cells, the cells that carry oxygen and carbon dioxide through the blood. This rather remarkable feat is thanks to hemoglobin , the pigment that makes red cells (and blood) look red. The red blood cells are also known as red corpuscles or erythrocytes (literally, red hollow vessels).
See the entire definition of RBC

Red blood cell: The blood cell that carries oxygen. Red cells contain hemoglobin and it is the hemoglobin which permits them to transport oxygen (and carbon dioxide). Hemoglobin, aside from being a transport molecule, is a pigment. It gives the cell its red color (and name).
See the entire definition of Red blood cell

Red blood cells: The blood cells that carry oxygen. Red cells contain hemoglobin and it is the hemoglobin which permits them to transport oxygen (and carbon dioxide). Hemoglobin, aside from being a transport molecule, is a pigment. It gives the cells their red color (and their name).
See the entire definition of Red blood cells

Red cell count: The number of red blood cells (RBCs) in a volume of blood. The normal range varies slightly between laboratories but is generally between 4.2 - 5.9 million cells/cmm. This can also be referred to as the erythrocyte count and can be expressed in international units as 4.2 - 5.9 x 1012 cells per liter.

Red cell distribution width: A measurement of the variability of red blood cell size. Higher numbers indicate greater variation in size. The normal range for the red cell distribution width (RDW) is 11 - 15. The RDW is a standard part of the complete blood count .
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Red cells: Short for red blood cells, the oxygen/carbon dioxide carrying cells in blood. Also known acronymically as RBC's, red corpuscles or erythrocytes (literally, red hollow vessels).

Syringe: A device used in medicine to inject fluid into or withdraw fluid from the body. Medical syringes consist of a needle attached to a hollow cylinder that is fitted with a sliding plunger. The downward movement of the plunger injects fluid; upward movement withdraws fluid.
See the entire definition of Syringe

Thrombocytosis: See thrombocythemia.

Vein: A blood vessel that carries blood low in oxygen content from the body back to the heart. The deoxygenated form of hemoglobin (deoxyhemoglobin) in venous blood makes it appear dark. Veins are part of the afferent wing of the circulatory system which returns blood to the heart.
See the entire definition of Vein

Vital: Necessary to maintain life. Breathing is a vital function.

WBC: Commonly used abbreviation for a white blood cell.
See the entire definition of WBC

White blood cell: One of the cells the body makes to help fight infections. There are several types of white blood cells ( leukocytes ). The two most common types are the lymphocytes and neutrophils (also called polymorphonuclear leukocytes, PMNs, or "polys").
See the entire definition of White blood cell

White blood cell count (leukocyte count): The number of white blood cells (WBCs) in the blood. The WBC is usually measured as part of the CBC ( complete blood count ). White blood cells are the infection-fighting cells in the blood and are distinct from the red (oxygen-carrying) blood cells known as erythrocytes. There are different types of white blood cells, including neutrophils (polymorphonuclear leukocytes ; PMNs), band cells (slightly immature neutrophils), T-type lymphocytes (T cells), B-type lymphocytes (B cells), monocytes, eosinophils, and basophils. All the types of white blood cells are reflected in the white blood cell count. The normal range for the white blood cell count varies between laboratories but is usually between 4,300 and 10,800 cells per cubic millimeter of blood. This can also be referred to as the leukocyte count and can be expressed in international units as 4.3 - 10.8 x 109 cells per liter.
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 Complete Blood Count Main Article |  Glossary |  Complete Blood Count Index 




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Complete Blood Count (CBC)

What is histoplasmosis?

Histoplasmosis is a disease, usually affecting the lungs, caused by the Histoplasma capsulatum fungus. Although many people that are or have been infected with H. capsulatum do not appear ill, some people in the acute phase of the disease have a dry cough, fever, and chest pains and do feel ill. There are several types of histoplasmosis (acute, chronic, and disseminated, all with subtypes).

H. capsulatum was first described by Samuel Darling in 1906 within human tissue cells (histiocytes). In 1932, Katharine Dodd and Edna Tompkins made the first diagnosis of histoplasmosis in an infant. Since the 1930s, H. capsulatum has been found worldwide, but the majority of cases are found in river valleys in temperate regions of the world and in equatorial Africa (in Africa, H. capsulatum has a variant thick-walled yeast form termed H. duboisii). Often an outbreak occurs in a group of ...

Read the Histoplasmosis article »










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