Dr. Lee was born in Shanghai, China, and received his college and medical training in the United States. He is fluent in English and three Chinese dialects. He graduated with chemistry departmental honors from Harvey Mudd College. He was appointed president of AOA society at UCLA School of Medicine. He underwent internal medicine residency and gastroenterology fellowship training at Cedars Sinai Medical Center.
Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.
Hereditary colon cancer syndromes
are caused by specific inherited mutations that are sufficient in themselves to
cause colon polyps, colon cancers, and non-colonic cancers. Hereditary colon
cancer syndrome can affect multiple members of a family. Approximately 5% of all
colon cancers in the US are due to hereditary colon cancer syndromes. Patients
who have inherited one of these syndromes have an extremely high risk for
developing colon cancer, approaching 90%-100%. Fortunately, blood tests are now available to test for these
hereditary colon cancer syndromes, once a syndrome has been suspected within a
family.
Familial adenomatous polyposis
(FAP)
Familial adenomatous polyposis, or
FAP is a hereditary colon cancer syndrome in which the affected family
members develop large numbers (hundreds, sometimes thousands) of colon polyps
starting in their teens. Unless the condition is
detected and treated early (treatment involves removal of the colon), a family
member with the FAP syndrome is almost sure to develop colon cancer. Cancers
most commonly begin to appear when patients are in their 40's, but can appear
earlier. These patients also are at risk of developing other cancers such as
cancers of the thyroid gland, stomach, and the ampulla (the part of the duodenum into which the
bile ducts drain).
Attenuated familial adenomatous
polyposis (AFAP)
Attenuated familial adenomatous polyposis, or AFAP is a milder version of FAP. Affected
patients develop less than 100 colon polyps. Nevertheless, they are at high risk
of developing colon cancers at a young age. They are also at risk for stomach
and duodenal polyps.
Hereditary nonpolyposis colon
cancer (HNPCC)
Hereditary nonpolyposis colon cancer, or HNPCC, is a hereditary cancer
syndrome in which affected family members tend to develop colon cancers, usually
in the right colon, in their 30's to 40's. Certain HNPCC patients also are at
elevated risk for developing uterine cancer, stomach cancer, ovarian cancer, cancers
of the ureters (the tubes that connect the kidneys to the bladder), cancers of
the bile ducts (the ducts that drain bile from the liver to the intestines), and
cancer of the brain and skin.
MYH polyposis syndrome
The MYH polyposis syndrome is a recently discovered hereditary colon cancer
syndrome. Affected patients typically develop 10-100 polyps during their 40's
and are at high risk for developing colon cancer. The MYH syndrome is inherited
in an autosomal recessive manner with each parent contributing one copy of the
mutant gene. Most people with the MYH syndrome do not have a multigenerational
family history of polyps or cancer of the colon but may have brothers or sisters
with it.
Abdominal pain is pain in the belly and can be acute or chronic. Causes include inflammation, distention of an organ, and loss of the blood supply to an organ. Abdominal pain can reflect a major problem with one of the organs in the abdomen such as the appendix, gallbladder, large and small intestine, pancreas, liver, colon, duodenum, and spleen.
Colon cancer is a malignancy that arises from the inner lining of the colon. Most, if not all, of these cancers develop from colonic polyps. Removal of these precancerous polyps can prevent colon cancer.
Ulcerative colitis is a chronic inflammation of the colon. Symptoms include abdominal pain, diarrhea, and rectal bleeding. Ulcerative colitis is closely related to Crohn's disease, and together they are referred to as inflammatory bowel disease. Treatment depends upon the type of ulcerative colitis diagnosed.
Inflammation of the inner lining of the colon is referred to as colitis. Symptoms of the inflammation of the colon lining include diarrhea, pain, and blood in the stool. There are several causes of colitis including infection, ischemia of the colon, inflammatory bowel disease (Crohn's disease, Ulcerative colitis, or microscopic colitis). Treatment depends on the cause of the colitis.
Cancer is a disease caused by an abnormal growth of cells, also called malignancy. It is a group of 100 different diseases, and is not contagious. Cancer can be treated through chemotherapy, a treatment of drugs that destroy cancer cells.
A colon polyp is a benign tumor of the large intestine. Benign polyps do not invade nearby tissue or spread to other parts of the body. Benign polyps can easily be removed during colonoscopy and are not life threatening. If benign polyps are not removed from the large intestine, they can become malignant over time.
Anal cancer, cancer located at the end of the large intestine, has symptoms that include anal or rectal bleeding, anal pain or pressure, anal discharge or itching, a change in bowel movements, and/or a lump in the anal region. Treatment for anal cancer may involve radiation, chemotherapy, or surgery and depends upon the stage of the cancer, its location, whether cancer is eradicated after the first treatment, and whether the patient has HIV.
Though it's difficult to say why some people develop cancer while others don't, research shows that certain risk factors increase a person's odds of developing cancer. These risk factors include growing older, family history of cancer, diet, alcohol and tobacco use, and exposure to sunlight, ionizing radiation, certain chemicals, and some viruses and bacteria.
Digestion is the complex process of turning food you eat into the energy you need to survive. The digestive process also involves creating waste to be eliminated, and is made of a series of muscles that coordinate the movement of food.
Gardners' syndrome, or familial adenomatous polyposis (FAP), is an inherited condition in which cancer of the colon and rectum develop. Colon polyps and growths may develop as early as the teens. If these polyps are not removed, they will become cancerous. There are different inheritance patterns for familial adenomatous polyposis.
Disease prevention in men includes routine screening tests that are part of basic prevention medicine. Take an active role in your own health care and discuss screening tests with your doctor early in life. Age of screening and timing of screening depends upon the condition being assessed.
Disease prevention in women includes screening tests that are a basic part of prevention medicine. All screening tests
are commonly available through your general doctor. Some specialized tests may be available elsewhere.
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