How does Colocynth work?

Colocynth contains the chemical cucurbitacin, which is extremely irritating to the mucous membranes, including the mucous membranes in the stomach and intestines.

Are there safety concerns?

Colocynth is UNSAFE for use. It was banned by the Food and Drug Administration (FDA) in 1991.

Ingestion of even very small amounts of colocynth can cause severe irritation of the stomach and intestine lining, bloody diarrhea, kidney damage, bloody urine, and inability to urinate. Other side effects include convulsions, paralysis, and death. 

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Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.