colistimethate-injectable (cont.)
PRECAUTIONS: Tell your doctor your medical history, especially of: kidney problems, any allergies. This drug may make you dizzy or drowsy. Use caution engaging in activities requiring alertness such as driving or using machinery. Caution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. Based on information for similar drugs, this medication may pass into breast milk. Therefore, consult your doctor before breast-feeding.
DRUG INTERACTIONS: This drug is not recommended for use with aminoglycoside antibiotics (e.g., gentamicin, tobramycin), polymyxin, or sodium cephalothin. Using this medication with these products may cause serious nerve side effects or kidney problems. Ask your doctor or pharmacist for more details. Tell your doctor of all prescription and nonprescription medication you may use, especially: certain muscle relaxants (e.g., curare-like drugs such as decamethonium, ether, gallamine, sodium citrate, succinylcholine, or tubocurarine), live vaccines (e.g., oral polio vaccine). Do not start or stop any medicine without doctor or pharmacist approval.
OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. Symptoms of overdose may include: loss of coordination, uncontrolled eye movements (nystagmus), confusion, severe trouble breathing.
NOTES: This medication has been prescribed for your current condition only. Do not use it later for another infection unless told to do so by your doctor. A different medication may be necessary in those cases. Do not share this medication with others. Laboratory and/or medical tests (e.g., creatinine, BUN) will be performed to monitor your progress.
MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
STORAGE: Store the unmixed/powder vials at room temperature between 59 and 86 degrees F (15 to 30 degrees C). Do not freeze. Once mixed, the suspension is good for 7 days and should be refrigerated between 36 and 46 degrees F (2 to 8 degrees C). After mixing and subsequent dilution with IV fluids, this product is stable at room temperature or refrigerated (below 77 degrees F or 25 degrees C) for 24 hours.
Last Editorial Review: 3/2/2005
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