Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.
Granules: 5 gm/ packet or bulk (5gm/teaspoonful) in canisters
Tablets: 1 gm.
Colestipol binds many different compounds in the gastrointestinal tract, thereby inhibiting their absorption into the body. For
example, colestipol can bind with and decrease the oral absorption of
carbamazepine (Tegretol), diuretics such as
hydrochlorothiazide (found in
Dyazide, Maxzide) and
propranolol (Inderal), tetracyclines,
vitamins (vitamins A, D, and K). Colestipol can bind with and
inhibit the absorption of thyroid hormones. Colestipol also can bind with
ursodiol (Actigall, Urso). Separating the doses of colestipol and these other compounds by
several hours should prevent binding with colestipol. Generally, other
should be administered one hour before colestipol or 4 hours after colestipol is
Colestipol binds to
vitamin K, a vitamin which is required by the liver to
make the factors that allow blood to clot. Colestipol, by reducing the action of
vitamin K, may exaggerate the effect of
(Coumadin), reducing the body's ability to
form blood clots. This interaction could lead to abnormal bleeding. On the other
hand, colestipol can bind with warfarin directly and inhibit the absorption of
warfarin. To avoid this interaction, doses of warfarin and colestipol should be
separated by at least 4-6 hours.
Colestipol is closely related to cholestyramine. Cholestyramine has been more
extensively studied than colestipol. Therefore, there are several drug
interactions which have been described with cholestyramine for which data is
lacking with colestipol. It would be prudent to assume that a similar
interactions exist for both drugs and to separate ingestion of colestipol from
the other drugs by several hours. These interactions with cholestyramine