colestipol, Colestid (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

SIDE EFFECTS: The most common adverse effect is constipation. Other less frequent side effects are:

Rarely, ulcers, reduced absorption of nutrients, fatty stools, and stomach or intestinal bleeding may occur.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Granules: 5 gm/ packet or bulk (5gm/teaspoonful) in canisters. Tablets: 1 gm.

STORAGE: Tablets and granules should be stored at room temperature, 20 C to 25 C (68 F to 77 F).

DOSING: Colestipol is most often prescribed in 2 to 4 divided doses but may also be prescribed once daily. The usual adult dose is 2-16 gm of tablets administered once or twice daily or 5-30 grams of granules once daily or 4 times daily.

Tablets should not be cut, crushed or chewed. Granules should be mixed in three ounces of fluid (water or fruit juice).

DRUG INTERACTIONS: Colestipol binds many different compounds in the gastrointestinal tract, thereby inhibiting their absorption into the body. For example, colestipol can bind with and decrease the oral absorption of carbamazepine (Tegretol), diuretics such as hydrochlorothiazide (found in Dyazide, Maxzide) and furosemide (Lasix), propranolol (Inderal), tetracyclines, and fat-soluble vitamins (vitamins A, D, and K). Colestipol can bind with and inhibit the absorption of thyroid hormones. Colestipol also can bind with ursodiol (Actigall, Urso).

Separating the doses of colestipol and these other compounds by several hours should prevent binding with colestipol. Generally, other drugs should be administered one hour before colestipol or 4 hours after colestipol is administered.

Medically Reviewed by a Doctor on 2/24/2015


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