colchicine/probenecid - oral, Col-Benemid (cont.)

DRUG INTERACTIONS: See also How to Use and Precautions sections.The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.Some products that may interact with this drug include: drugs that can increase uric acid in the blood (such as pyrazinamide, "water pills"/diuretics including hydrochlorothiazide).This medication can slow down the removal of other medications from your body, which may affect how they work or increase the risk of serious side effects. Examples include ketoprofen, methotrexate, pralatrexate, rifampin, antibiotics (including penicillin, cephalosporins), among others.Other medications can affect the removal of this medication from your body, which may affect how this drug works or increase the risk of serious side effects. Examples include azole antifungals (such as itraconazole, ketoconazole), cyclosporine, HIV medications (such as ritonavir), macrolide antibiotics (such as clarithromycin, erythromycin), telithromycin, verapamil, among others.Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (aspirin, NSAIDs such as ibuprofen, naproxen) that can decrease the effect of this drug. However, if your doctor has directed you to take low-dose aspirin for heart attack or stroke prevention (usually at dosages of 81-325 milligrams a day), you should continue taking the aspirin unless your doctor instructs you otherwise. Ask your doctor or pharmacist for more details.This medication may rarely cause a certain serious (even fatal) muscle damage (rhabdomyolysis). This muscle damage releases substances that can lead to serious kidney problems. The risk may be increased if other drugs that may also cause rhabdomyolysis are taken along with this drug. Some affected drugs include: atorvastatin, digoxin, gemfibrozil, fenofibrate, pravastatin, simvastatin, among others.This medication may interfere with certain laboratory tests (including urine glucose tests), possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug.This document does not contain all possible drug interactions. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious medication problems.

Medically Reviewed by a Doctor on 4/16/2014

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