colchicine, Colcrys (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

The recommended doses of colchicine for FMF are:

  • Children 4-6 years old: 0.3 to 1.8 mg daily
  • Children 6-12 years old: 0.6 to 1.8 mg daily
  • Adults and adolescents older than 12 years: 1.2 to 2.4 mg daily

Total daily doses may be administered in two divided doses. Doses should be increased by 0.3 mg daily as tolerated until symptoms are controlled or maximum daily doses are reached. Doses should be decreased by 0.3 mg daily if side effects occur.

DRUG INTERACTIONS: Several drugs reduce the breakdown and elimination of colchicine from the body by reducing the activity of enzymes that breakdown colchicine. In order to avoid side effects from colchicine the dose of colchicine should be reduced when it is combined with or used within 14 days of drugs that reduce its elimination.

Examples of drugs that reduce the elimination of colchicine include:

Medically Reviewed by a Doctor on 12/26/2014

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