colchicine, Colcrys (cont.)

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DOSING:

The recommended dose of colchicine for acute gout is:

  • 1.2 mg at the first sign of symptoms followed by 0.6 mg one hour later.
  • The maximum dose over a one hour period is 1.8 mg.
  • In clinical trials 1.8 mg of colchicine administered over 1 hour was as effective as 4.8 mg administered over 6 hours, and patients experienced fewer side effects.
  • The recommended dose for preventing flares of gout in individuals older than 16 years of age is 0.6 mg once or twice daily.

The recommended doses of colchicine for FMF are:

  • Children 4-6 years old: 0.3 to 1.8 mg daily
  • Children 6-12 years old: 0.6 to 1.8 mg daily
  • Adults and adolescents older than 12 years: 1.2 to 2.4 mg daily

Total daily doses may be administered in two divided doses. Doses should be increased by 0.3 mg daily as tolerated until symptoms are controlled or maximum daily doses are reached. Doses should be decreased by 0.3 mg daily if side effects occur.

DRUG INTERACTIONS: Several drugs reduce the breakdown and elimination of colchicine from the body by reducing the activity of enzymes that breakdown colchicine. In order to avoid side effects from colchicine the dose of colchicine should be reduced when it is combined with or used within 14 days of drugs that reduce its elimination.

Examples of drugs that reduce the elimination of colchicine include:



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