colchicine, Colcrys (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

SIDE EFFECTS: The most common side effects of colchicine are dose-related and include:

WARNING: Colchicine can damage the bone marrow causing severe anemia, low white blood counts, and low platelets. Reduced white blood cell counts may increase the risk of infections. All patients taking colchicine long-term require monitoring of their blood counts.

Colchicine also may cause muscle pain (myopathy) or severe muscle breakdown (rhabdomyolysis). Patients with renal or liver dysfunction or taking some other drugs (for example, simvastatin and other statins, gemfibrozil, fenofibrate), which also affect muscle tissue, are at a higher risk of developing rhabdomyolysis.



PREPARATIONS: Tablets: 0.6 mg

STORAGE: Colchicine should be stored between 20 and 25 C (68-77 F)


The recommended dose of colchicine for acute gout is:

  • 1.2 mg at the first sign of symptoms followed by 0.6 mg one hour later.
  • The maximum dose over a one hour period is 1.8 mg.
  • In clinical trials 1.8 mg of colchicine administered over 1 hour was as effective as 4.8 mg administered over 6 hours, and patients experienced fewer side effects.
  • The recommended dose for preventing flares of gout in individuals older than 16 years of age is 0.6 mg once or twice daily.
Medically Reviewed by a Doctor on 12/26/2014

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