colchicine, Colcrys (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
WARNING: Colchicine can damage the bone marrow causing severe anemia, low white blood counts, and low platelets. Reduced white blood cell counts may increase the risk of infections. All patients taking colchicine long-term require monitoring of their blood counts.
Colchicine also may cause muscle pain (myopathy) or severe muscle breakdown (rhabdomyolysis). Patients with renal or liver dysfunction or taking some other drugs (for example, simvastatin and other statins, gemfibrozil, fenofibrate), which also affect muscle tissue, are at a higher risk of developing rhabdomyolysis.
GENERIC AVAILABLE: No
PREPARATIONS: Tablets: 0.6 mg
STORAGE: Colchicine should be stored between 20 and 25 C (68-77 F)
The recommended dose of colchicine for acute gout is:
The recommended doses of colchicine for FMF are:
Total daily doses may be administered in two divided doses. Doses should be increased by 0.3 mg daily as tolerated until symptoms are controlled or maximum daily doses are reached. Doses should be decreased by 0.3 mg daily if side effects occur.
DRUG INTERACTIONS: Several drugs reduce the breakdown and elimination of colchicine from the body by reducing the activity of enzymes that breakdown colchicine. In order to avoid side effects from colchicine the dose of colchicine should be reduced when it is combined with or used within 14 days of drugs that reduce its elimination.
Examples of drugs that reduce the elimination of colchicine include:
Medically Reviewed by a Doctor on 12/26/2014
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