PREPARATIONS: Tablets: 0.6 mg
DRUG INTERACTIONS: Several drugs reduce the breakdown and elimination of colchicine from the body by reducing the activity of enzymes that breakdown colchicine. In order to avoid side effects from colchicine the dose of colchicine should be reduced when it is combined with or used within 14 days of drugs that reduce its elimination.
Examples of drugs that reduce the elimination of colchicine include:
- atazanavir (Reyataz),
- clarithromycin (Biaxin),
- itraconazole (Sporanox),
- lopinavir/ritonavir (Kaletra),
- nelfinavir (Viracept),
- saquinavir (Invirase),
- telithromycin (Ketek),
- ritonavir (Norvir),
- amprenavir (Agenerase),
- aprepitant (Emend),
- diltiazem (Cardizem),
- fluconazole (Diflucan),
- fosamprenavir (Lexiva),
- grapefruit juice,
- verapamil (Calan),
- cyclosporine, and
- ranolazine (Ranexa).
Combining colchicine with statins, for example atorvastatin (Lipitor), simvastatin (Zocor), and lovastatin (Mevacor), Lopid (gemfibrozil), or fenofibrate increases the risk of muscle related adverse effects because these drugs also cause muscle related side effects.
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