colchicine, Colcrys

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is the dosage for colchicine?

The recommended dose of colchicine for acute gout is:

  • 1.2 mg at the first sign of symptoms followed by 0.6 mg one hour later.
  • The maximum dose over a one hour period is 1.8 mg.
  • In clinical trials 1.8 mg of colchicine administered over 1 hour was as effective as 4.8 mg administered over 6 hours, and patients experienced fewer side effects.
  • The recommended dose for preventing flares of gout in individuals older than 16 years of age is 0.6 mg once or twice daily.

The recommended doses of colchicine for FMF are:

  • Children 4-6 years old: 0.3 to 1.8 mg daily
  • Children 6-12 years old: 0.6 to 1.8 mg daily
  • Adults and adolescents older than 12 years: 1.2 to 2.4 mg daily

Total daily doses may be administered in two divided doses. Doses should be increased by 0.3 mg daily as tolerated until symptoms are controlled or maximum daily doses are reached. Doses should be decreased by 0.3 mg daily if side effects occur.

Which drugs or supplements interact with colchicine?

Several drugs reduce the breakdown and elimination of colchicine from the body by reducing the activity of enzymes that breakdown colchicine. In order to avoid side effects from colchicine the dose of colchicine should be reduced when it is combined with or used within 14 days of drugs that reduce its elimination.

Examples of drugs that reduce the elimination of colchicine include:

Combining colchicine with statins, for example atorvastatin (Lipitor), simvastatin (Zocor), and lovastatin (Mevacor), Lopid (gemfibrozil), or fenofibrate increases the risk of muscle related adverse effects because these drugs also cause muscle related side effects.

What else should I know about colchicine?

What preparations of colchicine are available?

Tablets: 0.6 mg

How should I keep colchicine stored?

Colchicine should be stored between 20 and 25 C (68-77 F)

Reference: Colcrys FDA Prescribing Information

Medically Reviewed by a Doctor on 6/29/2016

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