colchicine, Colcrys

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GENERIC NAME: colchicine

BRAND NAME: Colcrys

DRUG CLASS AND MECHANSIM: Colchicine is an oral drug used for treating acute gout and familial Mediterranean fever (FMF). In acute gout there is severe inflammation in response to the presence of uric acid crystals that form in bony joints. This causes severe pain, redness, and swelling of the affected joint(s). Colchicine is useful in suppressing inflammation caused by gout. The exact mechanism of action of colchicine is not known. It may involve reduction in crystallization of uric acid leading to a reduction in the inflammatory response. Colchicine is not an analgesic (pain killer), but it reduces pain caused by gout. The FDA approved colchicine in September 1977 without clinical studies. In July 2009 the FDA approved colchicine for gout flares and FMF.

PRESCRIPTION: Yes

GENERIC AVAILABLE: No

PREPARATIONS: Tablets: 0.6 mg

STORAGE: Colchicine should be stored between 20 and 25 C (68-77 F)

PRESCRIBED FOR: Colchicine is used for the treatment of acute flares of gout. It also is used for treating FMF in adults and children 4 years of age or older. Other unapproved uses of colchicine include treatment of pseudogout, amyloidosis, and scleroderma. These unapproved uses of colchicine require further evaluation.




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