coenzyme q10, ubiquinone, ubidecarenone

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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PREPARATIONS: Soft Gel Tablets: 100 and 300 mg; Capsule: 30, 50, 200, and 400 mg; Gummies: 100 mg

DRUG INTERACTIONS: Taking coenzyme Q10 with medications, herbs, or supplements that reduce blood pressure may cause too much reduction in blood pressure.

Coenzyme Q10 may help blood to clot. Therefore, it may reduce the blood thinning effect of warfarin (Coumadin).

PREGNANCY AND BREASTFEEDING SAFETY:

Coenzyme Q10 has been used safely by pregnant women starting at 20 weeks gestation until term.

It is not known if coenzyme Q10 is excreted in breast milk.

STORAGE: Coenzyme Q10 should be stored at room temperature 20 C to 25 C (68 F to 77 F).

DOSING:

  • Doses vary depending on the use. The typical dose for treating coenzyme Q10 deficiency is 150 mg daily.
  • High blood pressure is treated with 120 to 200 mg daily in two divided doses.
  • The dose for preventing migraine headaches is 100 mg three times daily.
  • Doses of 300 to 2400 mg per day have been used for treating Parkinson's disease.

DRUG CLASS AND MECHANISM:

  • Coenzyme Q10 or CoQ10 is naturally produced in the body and is present in the heart, kidney, pancreas, and liver.
  • It is a fat soluble antioxidant and an important chemical used in oxidative respiration for the Krebs cycle and the electron transport chain both of which are critical for the generation of energy that is used by all cells in the body.
  • Coenzyme Q10 levels decrease with age and may be low in people with heart diseases, Parkinson's, disease, cancers, muscular dystrophies, and diabetes.

Reference: US National Library of Medicine Medline Plus

Medically Reviewed by a Doctor on 1/13/2016

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