cocaine hydrochloride (cont.)

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PREPARATIONS: Topical solution: 4 % and 10%

STORAGE: Cocaine hydrochloride should be stored at 20 C to 25 C (68 F to 77 F).


  • The dose should not exceed 1 mg/kg. Dosing of cocaine is variable and is based on numerous factors including the area to be anesthetized, individual patient tolerance, vascularity of the tissue, and anesthetic technique.
  • The lowest possible dose should be utilized to achieve effective anesthesia.
  • Dose reductions should be utilized in children, the elderly, and debilitated patients.
  • Cocaine hydrochloride can be administered by means of cotton applicators, packs, sprays, or instilled into a cavity.

DRUG INTERACTIONS: Due to the risk for serious cardiac arrhythmias, severely elevated blood pressure, and additional stimulation of the brain, ergot alkaloids (for example, ergotamine), monoamine oxidase inhibitors or MAOIs (for example, iproniazid), and other sympathomimetics should not be combined with cocaine hydrochloride.

PREGNANCY: Cocaine hydrochloride should only be given to pregnant women if clearly needed. Cocaine is classified as FDA pregnancy risk category C (adverse effects in animals but insufficient human data).

NURSING MOTHERS: Cocaine is excreted in breast milk and may cause adverse effects in the nursing infant. The American Association of Pediatrics recommends against the use of cocaine during breastfeeding. Due to the potential for serious side effects in the nursing infant, it is recommended that nursing be discontinued during cocaine use.


FDA Prescribing Information.

National Institute on Drug Abuse: The Science of Drug Abuse & Addiction. Cocaine.

Medically Reviewed by a Doctor on 6/1/2015

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