Lotrisone (clotrimazole and betamethasone topical cream and lotion)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

How much Lotrisone should I use (dosage)?

  • Lotrisone cream is gently massaged into the affected skin and surrounding area in the morning and evening. The treated skin should not be bandaged, covered, or wrapped in order to avoid excessive absorption of Lotrisone into the body.
  • Lotrisone cream or lotion should not be used for more than 2 weeks for treatment of tinea corporis or tinea cruris. If there is no clinical improvement after one week of treatment, the diagnosis should be reviewed.
  • Lotrisone should not be used longer than 4 weeks for treatment of tinea pedis. If there is no clinical improvement after 2 weeks of treatment, the diagnosis should be reviewed. These limits on duration of use are based on the clinical studies that were used by the FDA to approve Lotrisone and concerns that with longer use absorption of betamethasone might be enough to have effects on the body.
  • Amounts greater than 45 g per week of Lotrisone cream or amounts greater than 45 mL per week of Lotrisone lotion should not be used.

What drugs or supplements interact with Lotrisone?

  • Long-term use or withdrawal of topical corticosteroids may aggravate psoriasis. Therefore, there should be an interval of at least 1 week between the discontinuance of topical steroids and the starting of psoriasis treatment with anthralin (Psoriatec).

Is Lotrisone safe to use if I'm pregnant or breastfeeding?

  • Safety of using Lotrisone during pregnancy has not been evaluated.
  • It is not known whether clotrimazole or betamethasone is secreted in breast milk.

What else should I know about Lotrisone?

What preparations of are available?
How should I keep this medicine stored?
  • Lotrisone can be stored at room temperature, cream at 2 C to 30 C (36 F to 86 F) and lotion at 15 C to 30 C (59 F to 86 F).
How does Lotrisone work?
  • Lotrisone prevents growth of several types of fungi by preventing production of the membranes that surround fungal cells. Betamethasone is a synthetic corticosteroid that is used topically on the skin. Corticosteroids suppress inflammation as well as the body's immune response.
When was Lotrisone approved by the FDA?
  • The FDA approved Lotrisone cream in July 1984.

Reference: FDA Prescribing Information

Medically Reviewed by a Doctor on 2/27/2017

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