clotrimazole and betamethasone, Lotrisone (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
PREPARATIONS: Cream or lotion: 1% clotrimazole and 0.05% betamethasone
DRUG INTERACTIONS: Long-term use or withdrawal of topical corticosteroids may aggravate psoriasis. Therefore, there should be an interval of at least 1 week between the discontinuance of topical steroids and the starting of psoriasis treatment with anthralin (Psoriatec).
PREGNANCY AND BREASTFEEDING SAFETY: Safety of using Lotrisone during pregnancy has not been evaluated.
It is not known whether clotrimazole or betamethasone is secreted in breast milk.
STORAGE: Lotrisone can be stored at room temperature, cream at 2 C to 30 C (36 F to 86 F) and lotion at 15 C to 30 C (59 F to 86 F).
DOSING: Lotrisone cream is gently massaged into the affected skin and surrounding area in the morning and evening. The treated skin should not be bandaged, covered, or wrapped in order to avoid excessive absorption of Lotrisone into the body.
Lotrisone cream or lotion should not be used for more than 2 weeks for treatment of tinea corporis or tinea cruris. If there is no clinical improvement after one week of treatment, the diagnosis should be reviewed. Lotrisone should not be used longer than 4 weeks for treatment of tinea pedis. If there is no clinical improvement after 2 weeks of treatment, the diagnosis should be reviewed. These limits on duration of use are based on the clinical studies that were used by the FDA to approve Lotrisone and concerns that with longer use absorption of betamethasone might be enough to have effects on the body. Amounts greater than 45 g per week of Lotrisone cream or amounts greater than 45 mL per week of Lotrisone lotion should not be used.
DRUG CLASS AND MECHANISM: Lotrisone is a cream or lotion consisting of a combination of the drugs clotrimazole and betamethasone. Clotrimazole is an anti-fungal drug related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and miconazole (Micatin, Monistat). It prevents growth of several types of fungi by preventing production of the membranes that surround fungal cells. Betamethasone is a synthetic corticosteroid that is used topically on the skin. Corticosteroids suppress inflammation as well as the body's immune response.
Medically reviewed by Eni Williams, PharmD
Reference: FDA Prescribing Information
Medically Reviewed by a Doctor on 3/28/2016
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