clopidogrel (Plavix) (cont.)

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Medical and Pharmacy Editor:

PRESCRIBED FOR: Clopidogrel is used for preventing strokes, heart attacks, and death in individuals who have had a previous stroke, unstable angina, heart attack or have peripheral arterial disease (PAD). The combination of clopidogrel and aspirin is better than aspirin or clopidogrel alone in preventing another heart attack but the risk of bleeding is higher.

SIDE EFFECTS: The tolerability of clopidogrel is similar to that of aspirin. The more common side effects of clopidogrel are:

Ticlopidine (Ticlid) is an antiplatelet medication quite similar to clopidogrel. It has been associated with a severe reduction in white blood cell count in between 0.8% and 1% of persons. The risk of this dangerous side effect with clopidogrel is about 0.04%, much less than with ticlopidine but twice that of aspirin.

Clopidogrel rarely causes a condition called thrombotic thrombocytopenic purpura (TTP) in one out of every 250,000 people. TTP is a serious condition in which blood clots form throughout the body. Blood platelets, which participate in clotting, are consumed, and the result can be bleeding because enough platelets are no longer left to allow blood to clot normally. For comparison, the related drug, ticlodipine (Ticlid), causes TTP 17-50 times more frequently than clopidogrel.

Medically Reviewed by a Doctor on 12/30/2014

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