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November 22, 2009
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 clopidogrel Main Article |  Glossary |  clopidogrel Index 

clopidogrel bisulfate, Plavix Glossary of Terms

The following are health and medical definitions of terms that appear in the clopidogrel bisulfate, Plavix article.

Abdominal: Relating to the abdomen, the belly , that part of the body that contains all of the structures between the chest and the pelvis . The abdomen is separated anatomically from the chest by the diaphragm , the powerful muscle spanning the body cavity below the lungs .
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Abdominal pain: Pain in the belly (the abdomen). Abdominal pain can come from conditions affecting a variety of organs. The abdomen is an anatomical area that is bounded by the lower margin of the ribs above, the pelvic bone (pubic ramus) below, and the flanks on each side. Although abdominal pain can arise from the tissues of the abdominal wall that surround the abdominal cavity (the skin and abdominal wall muscles), the term abdominal pain generally is used to describe pain originating from organs within the abdominal cavity (from beneath the skin and muscles). These organs include the stomach, small intestine, colon, liver, gallbladder, and pancreas.
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Aleve: See: Naproxen.

Aspirin: A good example of a tradename that entered into the language, Aspirin was once the Bayer trademark for acetylsalicylic acid .
See the entire definition of Aspirin

Atherosclerotic: Pertaining to atherosclerosis, the process of progressive thickening and hardening of the walls of arteries from fat deposits on their inner lining. Atherosclerotic heart disease is the leading cause of death in the US.

Blood: The familiar red fluid in the body that contains white and red blood cells, platelets, proteins, and other elements. The blood is transported throughout the body by the circulatory system. Blood functions in two directions: arterial and venous. Arterial blood is the means by which oxygen and nutrients are transported to tissues while venous blood is the means by which carbon dioxide and metabolic by-products are transported to the lungs and kidneys, respectively, for removal from the body.

Blood clot: Blood that has been converted from a liquid to a solid state. Also called a thrombus .
See the entire definition of Blood clot

Breast : The breast refers to the front of the chest or, more specifically, to the mammary gland. The mammary gland is a milk producing gland. It is composed largely of fat. Within the mammary gland is a complex network of branching ducts. These ducts exit from sac-like structures called lobules, which can produce milk in females. The ducts exit the breast at the nipple.
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Breast milk: Milk from the breast . Human milk contains a balance of nutrients that closely matches infant requirements for brain development, growth and a healthy immune system . Human milk also contains immunologic agents and other compounds that act against viruses , bacteria , and parasites. Since an infant's immune system is not fully developed until age 2, human milk provides a distinct advantage over formula.
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Cell: The basic structural and functional unit in people and all living things. Each cell is a small container of chemicals and water wrapped in a membrane .
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Claudication : Limping. The word "claudication" comes from the Latin "claudicare" meaning to limp. The Roman emperor Claudius (who ruled from A.D. 41-54) was so named because he limped, probably because of a birth defect.
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Condition: The term "condition" has a number of biomedical meanings including the following:

  1. An unhealthy state, such as in "this is a progressive condition."
  2. A state of fitness, such as "getting into condition."
  3. Something that is essential to the occurrence of something else; essentially a "precondition."
  4. As a verb: to cause a change in something so that a response that was previously associated with a certain stimulus becomes associated with another stimulus; to condition a person, as in behavioral conditioning.

Diarrhea : A familiar phenomenon with unusually frequent or unusually liquid bowel movements, excessive watery evacuations of fecal material. The opposite of constipation . The word "diarrhea" with its odd spelling is a near steal from the Greek "diarrhoia" meaning "a flowing through." Plato and Aristotle may have had diarrhoia while today we have diarrhea. There are myriad infectious and noninfectious causes of diarrhea.
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Disease: Illness or sickness often characterized by typical patient problems (symptoms) and physical findings (signs). Disruption sequence: The events that occur when a fetus that is developing normally is subjected to a destructive agent such as the rubella (German measles) virus.

Enzyme: A protein (or protein-based molecule) that speeds up a chemical reaction in a living organism. An enzyme acts as catalyst for specific chemical reactions , converting a specific set of reactants (called substrates) into specific products. Without enzymes, life as we know it would not exist.
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FDA: The Food and Drug Administration, an agency within the U.S. Public Health Service, which is a part of the Department of Health and Human Services.
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Generic: 1. The chemical name of a drug. 2. A term referring to the chemical makeup of a drug rather than to the advertised brand name under which the drug may be sold. 3.A term referring to any drug marketed under its chemical name without advertising.

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Heart: The muscle that pumps blood received from veins into arteries throughout the body. It is positioned in the chest behind the sternum (breastbone; in front of the trachea, esophagus, and aorta; and above the diaphragm muscle that separates the chest and abdominal cavities. The normal heart is about the size of a closed fist, and weighs about 10.5 ounces. It is cone-shaped, with the point of the cone pointing down to the left. Two-thirds of the heart lies in the left side of the chest with the balance in the right chest.
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Heart attack: The death of heart muscle due to the loss of blood supply. The loss of blood supply is usually caused by a complete blockage of a coronary artery, one of the arteries that supplies blood to the heart muscle. Death of the heart muscle, in turn, causes chest pain and electrical instability of the heart muscle tissue.
See the entire definition of Heart attack

Ibuprofen: A non-steroidal anti-inflammatory drug (NSAID) commonly used to treat pain, swelling, and fever. Common brand names for Ibuprofen include Advil, Motrin, and Nuprin.

Infant: A child up to 2 years (24 months) of age.
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INR: International normalized ratio, a system established by the World Health Organization (WHO) and the International Committee on Thrombosis and Hemostasis for reporting the results of blood coagulation (clotting) tests. All results are standardized using the international sensitivity index for the particular thromboplastin reagent and instrument combination utilized to perform the test.
See the entire definition of INR

Itching: An uncomfortable sensation in the skin that feels as if something is crawling on the skin or in the skin, and makes the person want to scratch the affected area.
See the entire definition of Itching

Medication: 1. A drug or medicine. 2. The administration of a drug or medicine. (Note that "medication" does not have the dangerous double meaning of "drug.")

Metabolism: The whole range of biochemical processes that occur within us (or any living organism). Metabolism consists both of anabolism and catabolism (the buildup and breakdown of substances, respectively). The term is commonly used to refer specifically to the breakdown of food and its transformation into energy.

Naprosyn: See: Naproxen.

Naproxen : A non-steroidal anti-inflammatory drug (NSAID) used for the management of mild to moderate pain, fever, and inflammation . Naproxen blocks the enzyme cyclooxygenase that makes prostaglandins, resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced. Brand names for naproxen include Anaprox, Naprelan, Naprosyn, and Aleve.
See the entire definition of Naproxen

Nursing: 1) Profession concerned with the provision of services essential to the maintenance and restoration of health by attending the needs of sick persons. 2) Feeding a infant at the breast.

Pain: An unpleasant sensation that can range from mild, localized discomfort to agony. Pain has both physical and emotional components. The physical part of pain results from nerve stimulation. Pain may be contained to a discrete area, as in an injury, or it can be more diffuse, as in disorders like fibromyalgia . Pain is mediated by specific nerve fibers that carry the pain impulses to the brain where their conscious appreciation may be modified by many factors.
See the entire definition of Pain

Peripheral: Situated away from the center, as opposed to centrally located.
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Peripheral vascular disease: A disease of blood vessels outside the heart. Peripheral vascular disease (PVD) affects the peripheral circulation , as opposed to the cardiac circulation. PVD comprises diseases of both peripheral arteries and peripheral veins. PVD is sometimes incorrectly used as a synonym for peripheral artery disease (PAD). Intermittent claudication due to inadequate blood flow to the leg is an example of peripheral artery disease (PAD) while varicose veins and spider veins are examples of peripheral vein disease.
See the entire definition of Peripheral vascular disease

Pregnancy: The state of carrying a developing embryo or fetus within the female body. This condition can be indicated by positive results on an over-the-counter urine test, and confirmed through a blood test, ultrasound, detection of fetal heartbeat, or an X-ray. Pregnancy lasts for about nine months, measured from the date of the woman's last menstrual period (LMP). It is conventionally divided into three trimesters, each roughly three months long.
See the entire definition of Pregnancy

Pregnant: The state of carrying a developing fetus within the body.
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Prescription: A physician's order for the preparation and administration of a drug or device for a patient. A prescription has several parts. They include the superscription or heading with the symbol "R" or "Rx", which stands for the word recipe (meaning, in Latin, to take); the inscription, which contains the names and quantities of the ingredients; the subscription or directions for compounding the drug; and the signature which is often preceded by the sign "s" standing for signa (Latin for mark), giving the directions to be marked on the container.

Prothrombin: A coagulation (clotting) factor that is needed for the normal clotting of blood. A cascade of biochemical events leads to the formation of the final clot. In this cascade, prothrombin is a precursor to thrombin .
See the entire definition of Prothrombin

Prothrombin time: A clotting test, the prothrombin time is done to test the integrity of part of the clotting scheme. The prothrombin time is commonly used as a method of monitoring the accuracy of blood thinning treatment (anticoagulation) with COUMADIN. Familiarly called the "pro time," the test is the time needed for clot formation after a substance called thromboplastin (+ calcium) has been added to plasma.
See the entire definition of Prothrombin time

Purpura: 1. A hemorrhagic area in the skin. The area of bleeding within the skin, by definition, is greater than 3 millimeters in diameter. The appearance of the purpura depends on age of the lesion. Early purpura is red and becomes darker, then purple, and brown-yellow as it fades. Purpura does not blanch when touched.
2. A condition characterized by purpura such as immune thrombocytopenic purpura and Schönlein-Henoch purpura.

Rash : Breaking out (eruption) of the skin. Medically, a rash is referred to as an exanthem.
See the entire definition of Rash

Side effects: Problems that occur when treatment goes beyond the desired effect. Or problems that occur in addition to the desired therapeutic effect.
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Stomach: 1. The sac-shaped digestive organ that is located in the upper abdomen, under the ribs. The upper part of the stomach connects to the esophagus, and the lower part leads into the small intestine.
See the entire definition of Stomach

Stroke : The sudden death of some brain cells due to a lack of oxygen when the blood flow to the brain is impaired by blockage or rupture of an artery to the brain. A stroke is also called a cerebrovascular accident or, for short, a CVA.
See the entire definition of Stroke

Temperature: The temperature is the specific degree of hotness or coldness of the body. It is usually measured with a thermometer.
See the entire definition of Temperature

Vascular: Relating to the blood vessels of the body. The blood vessels of the body, as a group, are referred to as the vascular system.
See the entire definition of Vascular

Warfarin : An anticoagulant drug (brand names: Coumarin, Panwarfin, Sofarin) taken to prevent the blood from clotting and to treat blood clots and overly thick blood. Warfarin is also used to reduce the risk of clots causing strokes or heart attacks .
See the entire definition of Warfarin

White blood cell: One of the cells the body makes to help fight infections. There are several types of white blood cells ( leukocytes ). The two most common types are the lymphocytes and neutrophils (also called polymorphonuclear leukocytes, PMNs, or "polys").
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White blood cell count (leukocyte count): The number of white blood cells (WBCs) in the blood. The WBC is usually measured as part of the CBC ( complete blood count ). White blood cells are the infection-fighting cells in the blood and are distinct from the red (oxygen-carrying) blood cells known as erythrocytes. There are different types of white blood cells, including neutrophils (polymorphonuclear leukocytes ; PMNs), band cells (slightly immature neutrophils), T-type lymphocytes (T cells), B-type lymphocytes (B cells), monocytes, eosinophils, and basophils. All the types of white blood cells are reflected in the white blood cell count. The normal range for the white blood cell count varies between laboratories but is usually between 4,300 and 10,800 cells per cubic millimeter of blood. This can also be referred to as the leukocyte count and can be expressed in international units as 4.3 - 10.8 x 109 cells per liter.
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 clopidogrel Main Article |  Glossary |  clopidogrel Index 




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clopidogrel bisulfate, Plavix

What is aspirin?

Aspirin belongs to a class of medications called nonsteroidal antiinflammatory drugs (NSAIDs). Aspirin and other NSAIDs, for example, ibuprofen (for example, Motrin, Advil) and naproxen (for example, Aleve), are widely used to treat fever, pain, and inflammatory conditions such as arthritis, tendonitis, and bursitis. Aspirin is known chemically as acetyl salicylic acid and often abbreviated as ASA.

In addition to its effects on pain, fever, and inflammation, aspirin also has an important inhibitory effect on platelets in the blood. This antiplatelet effect is used to prevent blood clot formation inside arteries, particularly in individuals who have atherosclerosis (narrowing of the blood vessels) of their arteries, or are otherwise prone to develop blood clots in their arteries.

What are antiplatelet agents?

Antiplatelet agents are medications that block the formation of blood clots by pre...

Read the Aspirin and Antiplatelet Medications article »










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