Kapvay (clonidine extended-release)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

GENERIC NAME: clonidine (extended-release)

BRAND NAME: Kapvay (extended release)

DRUG CLASS AND MECHANISM: Kapvay is an oral medication used to treat attention deficit hyperactivity disorder (ADHD) in children and adolescents. This drug has been used to reduce blood pressure in adults for many years but has been approved for another indication by the FDA. Kapvay works by stimulating alpha-2 receptors in the brain. This may reduce hyperactivity symptoms by acting on parts of the brain that control emotion, attention and behavior. However the exact mechanism in treating ADHD is not known. The FDA approved Kapvay for pediatric patients aged 6–17 years in September 2010.



PREPARATIONS: Tablets: 0.1, 0.2 mg (extended release)

STORAGE: Kapvay tablets should be stored at room temperature 20 C to 25 C (68 F to 77 F) and protected from light.

PRESCRIBED FOR: Kapvay is used to treat attention deficit/hyperactivity disorder (ADHD) in children and adolescents aged 6 to 17 years. Kapvay can be used alone or in combination with stimulant medications to treat ADHD.

DOSING: Kapvay tablets should be swallowed whole, and should not be broken, chewed or crushed before swallowing. Kapvay tablets can be taken with or without food.

The recommended starting dose is 0.1 mg tablet once a day at bedtime. Doses may be increased by 0.1 mg per day every 7 days. In this case, doses should be given twice a day (either split equally, or the higher dose given at bedtime). The maximum daily dose of Kapvay is 0.4 mg per day.

DRUG INTERACTIONS: Kapvay should not be used with alcohol or other sedating drugs such as lorazepam (Ativan) due to increased risk of drowsiness.

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ADHD Symptoms in Children
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