- Tablets (immediate release): 0.1, 0.2, and 0.3 mg.
- Transdermal patches: 0.1, 0.2, and 0.3 mg delivered over 24 hours.
Clonidine can increase the sedating effects of other medications that cause sedation. Such drugs include
- narcotic pain relievers,
- sedatives such as alprazolam (Xanax) and clonazepam (Klonopin), and
Tricyclic antidepressants, for example, amitriptyline (Elavil, Endep), imipramine (Tofranil), desipramine (Norpramin), and clomipramine (Anafranil), can block the blood pressure lowering effects of clonidine. This may cause blood pressure to rise.
Since clonidine can reduce heart rate, it should be used cautiously in persons who are receiving other medications that lower heart rate such as beta-blockers, for example,
- atenolol (Tenormin),
- metoprolol (Lopressor),
- propranolol (Inderal),
- digoxin (Lanoxin),
- diltiazem (Cardizem) or
- verapamil (Calan Covera HS).
Abnormal heart rhythms can occur with the combination of clonidine and verapamil.
Cyclosporine (Sandimmune, Neoral) concentrations in the blood can increase when clonidine is begun. This interaction could result in kidney damage from the increased levels of cyclosporine.
Cocaine, pseudoephedrine, phenylephrine, and phenylpropanolamine also can reverse the blood pressure lowering effects of clonidine.
Quick GuideLowering Blood Pressure Pictures Slideshow: Exercise Tips for Getting Started
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