clonidine, Catapres, Catapres-TTS, Kapvay (cont.)

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Medical and Pharmacy Editor:

DRUG INTERACTIONS: Clonidine can increase the sedating effects of other medications that cause sedation. Such drugs include narcotic pain relievers, barbiturates, sedatives such as alprazolam (Xanax) and clonazepam (Klonopin) as well as ethanol.

Tricyclic antidepressants, for example, amitriptyline (Elavil, Endep), imipramine (Tofranil), desipramine (Norpramin), and clomipramine (Anafranil), can block the blood pressure lowering effects of clonidine. This may cause blood pressure to rise.

Since clonidine can reduce heart rate, it should be used cautiously in persons who are receiving other medications that lower heart rate such as beta-blockers, for example, atenolol (Tenormin), metoprolol (Lopressor), propranolol (Inderal)], digoxin (Lanoxin), diltiazem (Cardizem) or verapamil (Calan; Covera HS). Abnormal heart rhythms can occur with the combination of clonidine and verapamil.

Cyclosporine (Sandimmune, Neoral) concentrations in the blood can increase when clonidine is begun. This interaction could result in kidney damage from the increased levels of cyclosporine.

Nonsteroidal antiinflammatory drugs (NSAIDs), for example, ibuprofen (Motrin, Advil), naproxen (Naprosyn, Aleve), and nabumetone (Relafen) can reduce the antihypertensive effects of clonidine.

Medically Reviewed by a Doctor on 2/25/2015

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