clonidine, Catapres, Catapres-TTS, Jenloga (cont.)

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DOSING: The usual oral adult dose is 0.1–0.3 mg twice daily. The maximum oral dose is 2.4 mg daily. Patches should be applied to an area of hairless skin on the upper arm or torso, once every 7 days. When applying a new patch, a different area of skin should be used.

DRUG INTERACTIONS: Clonidine can increase the sedating effects of other medications that cause sedation. Such drugs include narcotic pain relievers, barbiturates, sedatives such as alprazolam (Xanax) and clonazepam (Klonopin) as well as ethanol.

Tricyclic antidepressants, for example, amitriptyline (Elavil, Endep), imipramine (Tofranil), desipramine (Norpramin), and clomipramine (Anafranil), can block the blood pressure lowering effects of clonidine. This may cause blood pressure to rise.

Since clonidine can reduce heart rate, it should be used cautiously in persons who are receiving other medications that lower heart rate such as beta-blockers, for example, atenolol (Tenormin), metoprolol (Lopressor), propranolol (Inderal)], digoxin (Lanoxin), diltiazem (Cardizem) or verapamil (Calan; Covera HS). Abnormal heart rhythms can occur with the combination of clonidine and verapamil.

Cyclosporine (Sandimmune, Neoral) concentrations in the blood can increase when clonidine is begun. This interaction could result in kidney damage from the increased levels of cyclosporine.



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