clomipramine (Anafranil) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Clomipramine should be avoided when possible or used cautiously with medications known to prolong the QTc interval. Examples of such medication are thioridazine (Mellaril), ziprasidone (Geodon), pimozide (Orap), and others.

Clomipramine increases the levels of serotonin in the brain. Co-administration with other medications that also increase serotonin levels increases the risk of serotonin syndrome. Symptoms of serotonin syndrome include rapid development of hyperthermia (high body temperature), high blood pressure, muscle rigidity, confusion, and delirium. Some medications that increase serotonin levels are monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, tricyclic antidepressants, and linezolid (Zyvox). For a complete list, please ask your doctor or pharmacist.

PREGNANCY: Clomipramine has not been adequately evaluated in pregnant women. Due to the lack of conclusive safety data, clomipramine should be used in pregnancy only if the benefit justifies the potential risk to the fetus. Clomipramine is classified as FDA pregnancy risk category C.

NURSING MOTHERS: Clomipramine is excreted into breast milk. Due to the lack of safety data, clomipramine is not recommended for use in females who are breastfeeding.

Medically Reviewed by a Doctor on 12/10/2014

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Finder Tool

Need help identifying pills and medications?
Use the pill identifier tool on RxList.

Back to Medications Index