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- What is clomipramine-oral, and how does it work (mechanism of action)?
- What brand names are available for clomipramine-oral?
- Is clomipramine-oral available as a generic drug?
- Do I need a prescription for clomipramine-oral?
- What are the side effects of clomipramine-oral?
- What is the dosage for clomipramine-oral?
- Which drugs or supplements interact with clomipramine-oral?
- Is clomipramine-oral safe to take if I'm pregnant or breastfeeding?
- What else should I know about clomipramine-oral?
What is clomipramine-oral, and how does it work (mechanism of action)?
Clomipramine (Anafranil) is a psychotropic agent used to treat obsessive-compulsive disorder (OCD). Clomipramine shares structural similarities with a class of antidepressants known as tricyclic antidepressants (TCAs).
The exact mechanism by which clomipramine exerts its therapeutic benefits is not fully understood. However, similar to other TCAs, clomipramine is thought to enhance the actions of norepinephrine and serotonin (chemical neurotransmitters in the brain that nerves use to communicate with one another) by blocking their reuptake and prolonging their activity. Clomipramine also has anticholinergic properties which means it blocks the action of another neurotransmitter, acetylcholine. This increases the risk for certain side effects. It also has weak antihistamine properties which appear to play a role in the mild sedative effects observed with use. Clomipramine was approved by the US FDA for the treatment of OCD in 1991.
What brand names are available for clomipramine-oral?
Is clomipramine-oral available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for clomipramine-oral?
What are the side effects of clomipramine-oral?
The most common side effects associated with the use of clomipramine include:
- upset stomach,
- dry mouth,
- sexual dysfunction,
- weight gain,
- low blood pressure,
- respiratory problems, and
- visual changes.
Less common but serious side effects include:
- hypersensitivity type reactions,
- suicidal ideation,
- serotonin syndrome, and
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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