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February 9, 2012
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clofazimine-oral, Lamprene

GENERIC NAME: CLOFAZIMINE - ORAL (klo-FAZZ-eh-meen)

BRAND NAME(S): Lamprene

Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage | Medical Alert

USES: This medication is used in the treatment of leprosy. It is often taken in combination with other anti-leprosy medication.

HOW TO USE: Take this medication by mouth with food as directed usually once a day. Take this for the full time prescribed. It may be necessary to continue on this medication for 2 to 3 years to ensure treatment is effective. Stopping therapy too soon may result in a relapse.

SIDE EFFECTS: More common side effects include: loss of appetite, diarrhea, nausea, vomiting, dry skin and discoloration (from pink to brownish-black) of the skin, stools, urine, saliva, sweat, tears or lining of the eyelids. Other side effects reported are changes in taste, dry or irritated eyes, headache, fever, increased blood sugar and an increased sensitivity to sunlight. Notify your doctor if any of these symptoms become bothersome. Notify your doctor immediately if any of these less common side effects occur: black or bloody stools, severe stomach pain, yellowing of the skin or eyes, unusual weakness, depression. If you notice other effects not listed above, contact your doctor or pharmacist.

PRECAUTIONS: Tell your doctor if you have: stomach disorders, any allergies. Use caution driving or operating machinery if this medication makes you drowsy. This medication should be used only if clearly needed during pregnancy. Discuss the risks and benefits with your doctor. This medication appears in breast milk. Consult your doctor before breast-feeding.

DRUG INTERACTIONS: Tell your doctor of any over-the-counter or prescription medication you may take. Do not start or stop any medicine without doctor or pharmacist approval.

OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly.

NOTES: Laboratory tests will be done periodically while taking this medication to monitor its effects. Discoloration of the skin is a temporary condition and will disappear over time after the medication has been stopped.




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clofazimine-oral, Lamprene

What is leprosy?

Leprosy is a disease caused by the bacteria Mycobacterium leprae, which causes damage to the skin and the peripheral nervous system. The disease develops slowly (from six months to 40 years!) and results in skin lesions and deformities, most often affecting the cooler places on the body (for example, eyes, nose, earlobes, hands, feet, and testicles). The skin lesions and deformities can be very disfiguring and are the reason that infected individuals historically were considered outcasts in many cultures. Although human-to-human transmission is the primary source of infection, three other species can carry and (rarely) transfer M. leprae to humans: chimpanzees, mangabey monkeys, and nine-banded armadillos. The disease is termed a chronic granulomatous disease, similar to tuberculosis, because it produces inflammatory nodules (granulomas) in the skin and nerves over time.

What is the history of lepro...

Read the Leprosy article »




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