clobetasol (Cormax, Embeline, Temovate, Olux, Clobex) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

Side effects that are less frequently reported with topical corticosteroid use include

  • irritation,
  • dryness,
  • hypertrichosis,
  • acneiform eruptions,
  • hypopigmentation,
  • perioral dermatitis,
  • allergic contact dermatitis,
  • maceration of the skin,
  • secondary infection,
  • skin atrophy,
  • stretch marks, and
  • heat rash (prickly heat).

Absorption of topical corticosteroids into the body may cause high blood glucose and other symptoms that are typical of oral corticosteroids.

In rare cases, treatment of psoriasis with corticosteroids has worsened the disease.

SIDE EFFECTS WARNING: Clobetasol propionate is a very strong topical corticosteroid that causes serious side effects if absorbed into the blood. If absorbed into the blood stream prolonged use of clobetasol can depress the ability of the body's adrenal glands to produce corticosteroids. Abruptly stopping the clobetasol in these individuals can cause symptoms of corticosteroid insufficiency. Therefore, topical corticosteroids should only be used for short term therapy and only applied to small area(s) of the body.



PREPARATIONS: Topical solution, Gel, Ointment, Liquid, Lotion, Spray, or Foam: 0.05%

STORAGE: Clobetasol should be stored at controlled room temperature between 20 C to 25 C (68 F to 77 F).

DOSING: Clobetasol should be applied to the affected area(s) of the skin or scalp twice daily, once in the morning and once at night. As topical clobetasol is a very strong corticosteroid, treatment should be limited to two consecutive weeks and no more than 50 g or 50 ml per week.

DRUG INTERACTIONS: Information on drug-drug interactions with topical clobetasol solution is not found in the prescribing information and medical literature.

PREGNANCY: There are no adequate and well-controlled studies evaluating the use of topical corticosteroids during pregnancy. Therefore, clobetasol and other topical corticosteroids should only be used during pregnancy if the potential benefit to the mother justifies the potential risk to the fetus. If used during pregnancy, use in large amounts or for long periods of time should be avoided.

NURSING MOTHERS: It is not known whether clobetasol is secreted in breast milk. Therefore, topical corticosteroids should be used cautiously in nursing mothers.

REFERENCE: FDA Prescribing Information.

Medically Reviewed by a Doctor on 6/19/2015

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