GENERIC NAME: clobetasol propionate
BRAND NAME: Cormax, Embeline, Temovate, Olux, Clobex
DRUG CLASS AND MECHANISM: Clobetasol propionate is a man-made corticosteroid that is used on the skin (topically). It is available as foam, shampoo, cream, gel, lotion, ointment, solution, and spray. It is similar to alclometasone (Aclovate), hydrocortisone valerate (Westcort), halobetasol (Ultravate) and several others. Topical clobetasol is used to treat certain scalp and skin conditions such as psoriasis, rashes, and dermatitis. Corticosteroids have potent anti-inflammatory actions and also suppress the immune response. Clobetasol is a very potent topical corticosteroid and should only be used for a short period of time. Long term use of topical clobetasol propionate can cause serious systemic side effects and should be avoided.
The FDA approved clobetasol on February 22, 1990.
PRESCRIBED FOR: Clobetasol is used for the short-term treatment of moderate to severe corticosteroid-responsive dermatoses, dermatoses of the scalp, and psoriasis in scalp and non scalp areas.
SIDE EFFECTS: The most common side effects reported include irritation in the area(s) the medication is applied to.
Other reported side effects include
- burning, stinging, tingling, scalp pustules,
- folliculitis (hair bumps),
- tightness of the scalp,
- hair loss, and
- eye irritation.
Side effects that are less frequently reported with topical corticosteroid use include
- folliculitis, increased hair (hypertrichosis ),
- acneiform eruptions,
- perioral dermatitis,
- allergic contact dermatitis,
- maceration of the skin,
- secondary infection,
- skin atrophy,
- stretch marks, and
Absorption of topical corticosteroids into the body may cause high blood glucose and other symptoms that are typical of oral corticosteroids.
In rare cases, treatment of psoriasis with corticosteroids has worsened the disease.
SIDE EFFECTS WARNING: Clobetasol propionate is a very strong topical corticosteroid that causes serious side effects if absorbed into the blood. If absorbed into the blood stream prolonged use of clobetasol can depress the ability of the body's adrenal glands to produce corticosteroids. Abruptly stopping hydrocortisone in these individuals can cause symptoms of corticosteroid insufficiency. Therefore, topical corticosteroids should only be used for short term therapy and only applied to small area(s) of the body.
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