GENERIC NAME: clindamycin phosphate, vaginal cream
BRAND NAME: Cleocin, Clindesse
DRUG CLASS AND MECHANISM: Clindamycin is an antibiotic used for treating serious infections. It is effective against several types of bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, and Staphylococcus epidermidis, and Propionibacterium acnes. It reduces growth of bacteria by interfering with their ability to make proteins. The FDA approved clindamycin for vaginal use in August 1972.
PRESCRIBED FOR: Clindamycin vaginal cream is used for treatment of bacterial vaginosis, an infection of the vagina. It can be used to treat non-pregnant women and pregnant women during the second and third trimester of pregnancy.
SIDE EFFECTS: The most common side effects of clindamycin cream are:
- vaginal moniliasis,
- vulvovaginal disorder,
- trichomonal vaginitis,
- moniliasis, and
GENERIC AVAILABLE: Yes
PREPARATIONS: Cream: 2%
STORAGE: Clindamycin should be stored at room temperature 20 C to 25 C (68 F to 77 F).
DOSING: The recommended dose is one full applicator of clindamycin phosphate vaginal cream 2% intravaginally, preferably at bedtime, for 3 or 7 days in non-pregnant women and for 7 days in pregnant women.
DRUG INTERACTIONS: Clindamycin give orally may act as a neuromuscular blocker. This means that it can increase the action of neuromuscular blocking drugs (for example, pancuronium and vecuronium). However, very little clindamycin is absorbed into the blood stream when given vaginally so the likelihood of drug interactions is less.
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