clindamycin phosphate vaginal cream, Cleocin

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GENERIC NAME: clindamycin phosphate, vaginal cream

BRAND NAME: Cleocin

DRUG CLASS AND MECHANISM: Clindamycin is an antibiotic used for treating serious infections. It is effective against several types of bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, and Staphylococcus epidermidis, and Propionibacterium acnes. It reduces growth of bacteria by interfering with their ability to make proteins. The FDA approved clindamycin for vaginal use in August 1972.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Cream: 2%

STORAGE: Clindamycin should be stored at room temperature 20 C to 25 C (68 to 77 F).

PRESCRIBED FOR: Clindamycin vaginal cream is used for treatment of bacterial vaginosis, an infection of the vagina. It can be used to treat non-pregnant women and pregnant women during the second and third trimester of pregnancy.

DOSING: The recommended dose is one full applicator of clindamycin phosphate vaginal cream 2% intravaginally, preferably at bedtime, for 3 or 7 days in non-pregnant women and for 7 days in pregnant women.

DRUG INTERACTIONS: Clindamycin give orally may act as a neuromuscular blocker. This means that it can increase the action of neuromuscular blocking drugs (for example, pancuronium and vecuronium). However, very little clindamycin is absorbed into the blood stream when given vaginally so the likelihood of drug interactions is less.

PREGNANCY: The frequency of congenital abnormalities was not increased when pregnant women used clindamycin during the second and third trimesters, and clindamycin vaginal cream is approved for use during the second and third trimesters of pregnancy. Clindamycin should not be used during the first trimester of pregnancy unless it is clearly needed because it has not been properly evaluated during the first trimester.

NURSING MOTHERS: Oral clindamycin is excreted in breast milk and should not be used by nursing mothers, or nursing should be stopped. It is not known whether clindamycin given vaginally is excreted in breast milk.

SIDE EFFECTS: The most common side effects of clindamycin cream are vaginal moniliasis, vulvovaginitis, vulvovaginal disorder, trichomonal vaginitis, moniliasis, and itching.

REFERENCE: FDA Prescribing Information.


Medically Reviewed by a Doctor on 5/15/2014



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