clindamycin vaginal suppository (Cleocin) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:


  • Insert 1 suppository into the vagina at night for 3 days.
  • Patients should avoid vaginal intercourse or vaginal products (such as tampons or douches) during treatment with clindamycin vaginal suppositories.


  • Clindamycin given orally may act as a neuromuscular blocker. This means it can increase the action of neuromuscular blocking drugs (for example, pancuronium and vecuronium). Less clindamycin is absorbed into the blood stream when given as a suppository so the likelihood of an interaction with these drugs is less likely.


  • The frequency of congenital abnormalities was not increased when pregnant women used oral clindamycin during the second and third trimesters.
  • Pregnant women who used clindamycin vaginal cream during the second trimester reported abnormal labor more frequently than those who received placebo.
  • Clindamycin vaginal suppositories have not been properly evaluated during the first trimester of pregnancy. They should only be used during the first trimester of pregnancy when they are clearly needed.
  • Oral clindamycin is excreted in breast milk and should not be used by nursing mothers or nursing should be stopped.
  • It is not known whether clindamycin from vaginal suppositories is excreted in breast milk.
Medically Reviewed by a Doctor on 12/31/2015

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