clindamycin, Cleocin T, Clinda-Derm (cont.)

Pharmacy Author:
Medical Editor:

PREPARATIONS: Gel, foam, lotion, solution, swab: 1%

DRUG INTERACTIONS: Clindamycin given orally may act as a neuromuscular blocker. This means it can increase the action of neuromuscular blocking drugs (for example, pancuronium and vecuronium) that block the contraction of muscles. Less clindamycin is absorbed into the blood stream when given topically so the likelihood of this drug interaction is less likely.

PREGNANCY AND BREASTFEEDING SAFETY: The frequency of congenital abnormalities was not increased when pregnant women used clindamycin during the second and third trimesters. Clindamycin has not been properly evaluated during the first trimester of pregnancy. It should only be used during the first trimester of pregnancy if it is clearly needed. Oral clindamycin is excreted in breast milk and either should not be used by nursing mothers or nursing should be stopped. It is not known whether clindamycin given topically is excreted in breast milk.

STORAGE: Clindamycin topical preparations should be stored at room temperature, 20 C to 25 C (68 F to 77 F).

DOSING: A thin film of the lotion, and solution should be applied to affected areas every 12 hours. A thin film of the foam should be applied to the affected areas once daily. The gel may be applied once or twice daily depending on the brand. The swab is used to apply a thin layer of clindamycin film to the affected area twice daily. Each swab should be used once and then discarded.

DRUG CLASS AND MECHANISM:

  • Clindamycin is an antibiotic used for treating several infections. It is effective against several types of bacteria such as Staphylococcus aureus, Streptococcus pneumoniae, Staphylococcus epidermidis, and Propionibacterium acnes.
  • It reduces growth of bacteria by interfering with their ability to make proteins.
  • The FDA approved clindamycin for topical (on the skin) use in July, 1980.

Medically reviewed by Omudhome Ogbru, PharmD

Reference: FDA Prescribing Information


Medically Reviewed by a Doctor on 1/19/2016


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