topical clindamycin (Cleocin T, Clindagel, ClindaDerm, Clindets, Evoclin)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

What is the dosage for topical clindamycin phosphate (Cleocin T, Clindagel, ClindaDerm, Clindets, Evoclin)?

  • A thin film of the lotion, and solution should be applied to affected areas every 12 hours.
  • A thin film of the foam should be applied to the affected areas once daily.
  • The gel may be applied once or twice daily depending on the brand.
  • The swab is used to apply a thin layer of clindamycin film to the affected area twice daily. Each swab should be used once and then discarded.

Which drugs or supplements interact with topical clindamycin phosphate (Cleocin T, Clindagel, ClindaDerm, Clindets, Evoclin)?

  • Clindamycin given orally may act as a neuromuscular blocker. This means it can increase the action of neuromuscular blocking drugs (for example, pancuronium and vecuronium) that block the contraction of muscles. Less clindamycin is absorbed into the blood stream when given topically so the likelihood of this drug interaction is less likely.

Is topical clindamycin phosphate (Cleocin T, Clindagel, ClindaDerm, Clindets, Evoclin) safe to use during pregnancy or while breastfeeding?

  • The frequency of congenital abnormalities was not increased when pregnant women used clindamycin during the second and third trimesters. Clindamycin has not been properly evaluated during the first trimester of pregnancy. It should only be used during the first trimester of pregnancy if it is clearly needed.
  • Oral clindamycin is excreted in breast milk and either should not be used by nursing mothers or nursing should be stopped. It is not known whether clindamycin given topically is excreted in breast milk.

What else should I know about topical clindamycin phosphate (Cleocin T, Clindagel, ClindaDerm, Clindets, Evoclin)?

What preparations of topical clindamycin phosphate (Cleocin T, Clindagel, ClindaDerm, Clindets, Evoclin) are available?
  • Gel, foam, lotion, solution, swab: 1%
How should I keep topical clindamycin phosphate (Cleocin T, Clindagel, ClindaDerm, Clindets, Evoclin) stored?
  • Clindamycin topical preparations should be stored at room temperature, 20 C to 25 C (68 F to 77 F).
How does topical clindamycin phosphate (Cleocin T, Clindagel, ClindaDerm, Clindets, Evoclin) work?
  • Clindamycin reduces growth of bacteria by interfering with their ability to make proteins.
When was topical clindamycin phosphate (Cleocin T, Clindagel, ClindaDerm, Clindets, Evoclin) approved by the FDA?
  • The FDA approved clindamycin for topical (on the skin) use in July, 1980.

Reference: FDA Prescribing Information

Medically Reviewed by a Doctor on 11/9/2016

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