GENERIC NAME: clindamycin phosphate, topical
BRAND NAME: Cleocin T, Clindagel, ClindaDerm, Clindets, Evoclin
GENERIC AVAILABLE: Yes
SIDE EFFECTS: The most common side effects of topical clindamycin are:
- skin redness
- oily skin
Some clindamycin topical solutions contain an alcohol base which will cause burning and irritation in the eye.
Possible serious side effects of clindamycin include:
Orally administered and injected clindamycin may cause severe colitis. Topical formulations of clindamycin may be absorbed from the skin surface, and diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of topical clindamycin.
PREPARATIONS: Gel, foam, lotion, solution, swab: 1%
DRUG INTERACTIONS: Clindamycin given orally may act as a neuromuscular blocker. This means it can increase the action of neuromuscular blocking drugs (for example, pancuronium and vecuronium) that block the contraction of muscles. Less clindamycin is absorbed into the blood stream when given topically so the likelihood of this drug interaction is less likely.
PREGNANCY AND BREASTFEEDING SAFETY: The frequency of congenital abnormalities was not increased when pregnant women used clindamycin during the second and third trimesters. Clindamycin has not been properly evaluated during the first trimester of pregnancy. It should only be used during the first trimester of pregnancy if it is clearly needed. Oral clindamycin is excreted in breast milk and either should not be used by nursing mothers or nursing should be stopped. It is not known whether clindamycin given topically is excreted in breast milk.
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