clindamycin, oral (Cleocin) (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:

To avoid throat irritation, clindamycin should be taken with a full glass of water.

DRUG INTERACTIONS: Clindamycin may act as a neuromuscular blocker. This means it can increase the action of neuromuscular blocking drugs (for example, pancuronium and vecuronium), which are used during surgery.

PREGNANCY: The frequency of congenital abnormalities was not increased when pregnant women used clindamycin during the second and third trimesters. Clindamycin should not be used during the first trimester of pregnancy unless it is clearly needed because it has not been properly evaluated during the first trimester of pregnancy.

NURSING MOTHERS: Clindamycin is excreted in breast milk and should not be used by nursing mothers or nursing should be stopped.

SIDE EFFECTS: The most common side effects of clindamycin are stomach pain and diarrhea. It also frequently causes nausea, vomiting, rash, and itching.

Clindamycin causes Clostridium difficile associated diarrhea (CDAD) because it can alter the normal bacteria in the colon and encourage overgrowth Clostridium difficile, a bacteria which causes inflammation of the colon (pseudomembranous colitis). Patients who develop signs of pseudomembranous colitis after starting clindamycin (diarrhea, fever, abdominal pain, and possibly shock) should contact their physician immediately.

REFERENCE: FDA Prescribing Information


Medically Reviewed by a Doctor on 4/16/2014


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