Cleft Palate and Cleft Lip (cont.)
Is it possible to prevent a cleft lip or cleft palate?
The large majority of infants experiencing cleft lip or cleft palate do not
have a genetic predisposition or obvious risk factors. During pregnancy, there
are issues that may increase the likelihood of producing a newborn with cleft
lip and/or cleft palate. These may include the following:
- Certain medications to help
prevent maternal seizures or migraine headaches (for example, topiramate [Topamax])
- Certain medications that are used as cancer chemotherapy (including
methotrexate [Rheumatrex, Trexall])
- Smoking cigarettes (no information yet regarding
- Alcohol consumption
- Lack of folic acid supplementation prior to conception and throughout the
Cleft Palate Foundation. <http://www.cleftline.org/parents-individuals/publications/support>
Jones, Kenneth Lyon. Smith's Recognizable Patterns of Human Malformation, 5th ed. Philadelphia, Pa.: WB Saunders Co., 1997.
Medically Reviewed by a Doctor on 7/9/2014