clarithromycin, Biaxin, Biaxin XL (cont.)

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DOSING: Clarithromycin may be taken with or without food. For most infections the recommended adult dose is 250-500 mg of immediate release tablets twice daily or 1000 mg of extended release tablets once daily for 7-14 days.

DRUG INTERACTIONS: Clarithromycin interacts with several drugs because it reduces the activity of liver enzymes that breakdown many drugs. This leads to increased blood levels and side effects from the affected drugs. Examples of such interactions include

Clarithromycin increases blood levels of sildenafil (Viagra, Revatio), tadalafil (Cialis, Adcirca), vardenafil (Levitra), theophylline and carbamazepine (Tegretol), thereby increasing side effects of these drugs.

Ritonavir (Norvir) and atazanavir (Reyataz) increase blood levels of clarithromycin while efavirenz (Sustiva), nevirapine (Viramune), rifampin, decrease blood levels of clarithromycin.



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