PREPARATIONS: Tablets (immediate or extended release): 250 and 500 mg. Suspension: 125 or 250 mg per 5 ml (teaspoonful).
DRUG INTERACTIONS: Clarithromycin interacts with several drugs because it reduces the activity of liver enzymes that breakdown many drugs. This leads to increased blood levels and side effects from the affected drugs. Examples of such interactions include
- olchicine (Colcrys),
- simvastatin (Zocor),
- lovastatin (Mevacor),
- atorvastatin (Lipitor),
- verapamil (Calan),
- amlodipine (Norvasc), and
- diltiazem (Carizem).
Clarithromycin increases blood levels of sildenafil (Viagra, Revatio), tadalafil (Cialis, Adcirca), vardenafil (Levitra), theophylline and carbamazepine (Tegretol), thereby increasing side effects of these drugs.
The occurrence of abnormal heart beats may increase when clarithromycin is combined with drugs that affect heart beat (for example, amiodarone [Coradone], quinidine [Quinidine Gluconate, Quinidine Sulfate], and disopyramide).
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