clarithromycin, Biaxin, Biaxin XL (cont.)
Omudhome Ogbru, PharmD
Omudhome Ogbru, PharmD
Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.
Medical and Pharmacy Editor:
SIDE EFFECTS: Clarithromycin generally is well tolerated, and side effects usually are mild and transient. Common side effects of clarithromycin are:
Other important side effects which are rare, but serious include:
Clarithromycin should be avoided by patients known to be allergic to clarithromycin or other chemically-related macrolide antibiotics, such as erythromycin. Treatment with clarithromycin and other antibiotics can alter the normal bacteria flora of the colon and permit overgrowth of C. difficile, a bacterium responsible for pseudomembranous colitis. Patients who develop pseudomembranous colitis as a result of antibiotics treatment may experience diarrhea, abdominal pain, fever, and sometimes even shock.
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets (immediate or extended release): 250 and 500 mg. Suspension: 125 or 250 mg per 5 ml (teaspoonful).
STORAGE: Tablets and suspension should be stored at room temperature 15 -30 C (59-86 F) in a tightly closed container. The oral suspension should not be refrigerated after mixing and should be used within 14 days.
DOSING: Clarithromycin may be taken with or without food. For most infections the recommended adult dose is 250-500 mg of immediate release tablets twice daily or 1000 mg of extended release tablets once daily for 7-14 days.
DRUG INTERACTIONS: Clarithromycin interacts with several drugs because it reduces the activity of liver enzymes that breakdown many drugs. This leads to increased blood levels and side effects from the affected drugs. Examples of such interactions include
Medically Reviewed by a Doctor on 12/30/2014
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