cisapride, Propulsid (cont.)
GENERIC AVAILABLE: no
PREPARATIONS: tablets: 10mg and 20mg
STORAGE: Tablets should be kept in a tight container and protected from light and moisture. Temperature should be kept between 15-30C (59-86F).
DOSING: Cisapride is given four times daily, 15 minutes before each meal and at bedtime. Anticholinergic medications can decrease the beneficial effect of cisapride.
DRUG INTERACTIONS: Cisapride should be avoided in patients suffering from intestinal obstruction or perforation. Since cisapride accelerates stomach emptying, it can increase absorption and effects of other medications. For example, the effects of sedatives such as alcohol and diazepam (Valium) can be accelerated when used together with cisapride. Oral anticoagulant (Coumadin) may have increased effects in some patients also taking cisapride. The coagulation times (protimes) may need to be closely monitored to avoid excessive anticoagulation and risks of bleeding. Safety in children has not been established.
PREGNANCY: Safety in pregnancy has not been established.
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