ciprofloxacin ophthalmic solution (Ciloxan)

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GENERIC NAME: ciprofloxacin ophthalmic solution

BRAND NAMES: Ciloxan

DRUG CLASS AND MECHANISM: Ciprofloxacin is an antibiotic that is used to treat bacterial infections. Ciprofloxacin belongs to the fluoroquinolone class of antibiotics which includes levofloxacin (Levaquin), ofloxacin (Floxin), gatifloxacin (Tequin), norfloxacin (Noroxin), moxifloxacin (Avelox), and others. Ciprofloxacin interferes with bacterial DNA uncoiling and replication, which ultimately leads to bacterial cell death. Ciprofloxacin, like other fluoroquinolone antibiotics, targets a wide range of bacteria. Targeted organisms include Pseudomonas aeruginosa, Serratia marcescens, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, and the viridans group of Streptococcus. Ciprofloxacin ophthalmic solution was approved in March 1998.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Ophthalmic Solution 0.3%

STORAGE: Ciprofloxacin solution should be stored at room temperature, between 15 C to 30 C (59 F to 86 F), or may be refrigerated and stored between 2 C to 8 C (36 F to 46 F). Protect from light.

PRESCRIBED FOR: Ciprofloxacin ophthalmic solution is prescribed for the treatment of ulcers on the eye surface (corneal ulcers) and bacterial infections of the eye.

DOSING: The dose for bacterial eye infections in adults and children 1 year old or greater is 1 to 2 drops every 2 hours in the infected eye for 2 days, followed by 1-2 drops every 4 hours for 5 days. For corneal ulcers in this population, instill 2 drops into the eye every 15 minutes for 6 hours, followed by 2 drops every 30 minutes for the rest of day 1. On day 2, 2 drops should be used every hour, followed by 2 drops every 4 hours on days 3 to 14.

DRUG INTERACTIONS: There are no known significant drug interactions with ciprofloxacin ophthalmic solution.

PREGNANCY: Use during pregnancy has not been adequately evaluated. Ophthalmic use may lead to some systemic absorption, so caution should be used.

NURSING MOTHERS: Oral and IV ciprofloxacin passes into breast milk. Ophthalmic use may lead to some absorption into the body, so caution should be used in nursing mothers.

SIDE EFFECTS: It is common to have white crust or crystals (precipitate) into the eye or on the eyelid during treatment; they dissolve in a few weeks. Other common side effects include an unpleasant taste in the mouth immediately after instilling the drop, redness, burning, numbness, itching, or discomfort of the eye, or the sensation that something is in the eye. The eye can also appear tired, stained, or swollen.

REFERENCE: FDA Prescribing Information.


Medically Reviewed by a Doctor on 5/20/2014



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