cimetidine, Tagamet HB

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

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GENERIC NAME: cimetidine

BRAND NAME: Tagamet HB

DISCONTINUED BRAND: Tagamet

DRUG CLASS AND MECHANISM: Cimetidine is a drug that blocks the production of acid by acid-producing cells in the stomach and can be administered orally, IM or IV. It belongs to a class of drugs called H2 (histamine-2) blockers that also includes ranitidine (Zantac), nizatidine (Axid), and famotidine (Pepcid). Histamine is a naturally-occurring chemical that stimulates cells in the stomach (parietal cells) to produce acid. H2-blockers inhibit the action of histamine on the cells, thus reducing the production of acid by the stomach. Since excessive stomach acid can damage the esophagus, stomach, and duodenum by reflux and lead to inflammation and ulceration, reducing stomach acid prevents and allows acid-induced inflammation and ulcers to heal. Cimetidine was approved by the FDA in 1977.

PRESCRIBED FOR: Cimetidine is used for the treatment of duodenal ulcers, active gastric ulcers, gastroesophageal reflux disease (GERD), pathological hypersecretory conditions (for example, Zollinger Ellison syndrome), heartburn and the prevention of gastrointestinal bleeding.

SIDE EFFECTS: Side effects due to cimetidine are rare and generally reversible once the medication is stopped. Minor side effects include:

Medically Reviewed by a Doctor on 4/14/2015

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