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- What is cilostazol, and how does it work (mechanism of action)?
- What brand names are available for cilostazol?
- Is cilostazol available as a generic drug?
- Do I need a prescription for cilostazol?
- What are the side effects of cilostazol?
- What is the dosage for cilostazol?
- Which drugs or supplements interact with cilostazol?
- Is cilostazol safe to take if I'm pregnant or breastfeeding?
- What else should I know about cilostazol?
What is cilostazol, and how does it work (mechanism of action)?
Cilostazol is a medication for the treatment of intermittent claudication, a condition caused by narrowing of the arteries that supply the legs with blood. Patients with intermittent claudication develop pain when they walk because not enough oxygen-containing blood reaches the active leg muscles. Cilostazol reduces the pain of intermittent claudication by dilating the arteries, thereby improving the flow of blood and oxygen to the legs. (It does this by decreasing the action of an enzyme, phosphodiesterase III.) It also reduces the ability of blood to clot. Cilostazol enables patients with intermittent claudication to walk longer and faster before developing pain. Cilostazol has a different mechanism of action than pentoxifylline (Trental), the other drug approved for intermittent claudication. (Pentoxifylline improves blood flow by making it easier for red blood cells to pass through vessels. It also decreases the viscosity of blood.). The FDA approved cilostazol in January 1999.
What brand names are available for cilostazol?
Is cilostazol available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for cilostazol?
What are the side effects of cilostazol?
The most common adverse effects of cilostazol are:
- abdominal pain,
- abnormal stool,
- upper respiratory tract infections,
- runny nose,
- fluid retention,
- dizziness and
- abnormal heartbeats.
Other important side effects which have also been reported with cilostazol include a reduction in numbers of white blood cells and platelets. Severe skin reactions also have been reported.
Cilostazol inhibits the enzyme phosphodiesterase III. Other drugs that inhibit this enzyme have caused death in individuals with heart failure. Therefore, individuals with heart failure should not use cilostazol.
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