Chondroitin Sulfate

Are there any interactions with medications?



Warfarin (Coumadin)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Warfarin (Coumadin) is used to slow blood clotting. There are several reports showing that taking chondroitin with glucosamine increases the effect of warfarin (Coumadin) on blood clotting. This can cause bruising and bleeding that can be serious. Don't take chondroitin if you are taking warfarin (Coumadin).

Dosing considerations for Chondroitin Sulfate.

The following doses have been studied in scientific research:

BY MOUTH:
  • For osteoarthritis: the typical dose of chondroitin sulfate is 800-2000 mg taken as a single dose or in two or three divided doses daily for up to 3 years.
APPLIED TO THE SKIN:
  • For osteoarthritis: a cream containing 50 mg/gram of chondroitin sulfate, 30 mg/gram of glucosamine sulfate, 140 mg/gram of shark cartilage, and 32 mg/gram of camphor has been used as needed for sore joints for up to 8 weeks.
INJECTED INTO THE MUSCLE:
  • For osteoarthritis: chondroitin sulfate (Matrix) has been injected into the muscle daily or twice weekly for 6 months.
INSERTED INTO THE BLADDER:
  • For urinary tract infections (UTIs): 50 mL of a specific solution containing chondroitin sulfate and hyaluronic acid (iAluRil, IBSA Farmaceutici), has been inserted into the bladder once weekly for 4 weeks, and then once or twice monthly for up to 5 months.
APPLIED TO THE EYE:
  • For cataracts: Several different eye drops containing sodium hyaluronate and chondroitin sulfate (DisCoVisc, Alcon Laboratories; Viscoat, Alcon Laboratories; DuoVisc, Alcon Laboratories; Viscoat, Alcon Laboratories; Provisc, Alcon Laboratories) have been used during cataract surgery.

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