choline magnesium salicylate, Trilisate (cont.)

Pharmacy Author:
Medical and Pharmacy Editor:
Medical and Pharmacy Editor:


For rheumatoid arthritis, osteoarthritis, other severe arthritis, and acute painful joints, the recommended starting dosage is 1500 mg given twice a day. The recommended dose range is 1000 to 3000 mg given every 8 to 12 hours.

For mild to moderate pain or fever, the usual dosage is 1000 mg to 1500 mg every 12 hours.

It should be taken with food to prevent an upset stomach. This drug should not be used in children or teens with chickenpox or flu symptoms.

DRUG INTERACTIONS: Choline magnesium salicylate, as other salicylates, should not be given within six weeks of influenza virus vaccine as this can increase risk of Reye's syndrome (a serious, often fatal disease that causes numerous detrimental effects to many organs, especially the brain and liver) due to unknown mechanisms.

When choline magnesium salicylate is used in combination with methotrexate (Rheumatrex, Trexall), an antimetabolite, the blood levels of methotrexate may increase, presumably because the elimination of methotrexate from the body is reduced. This may lead to more methotrexate-related side effects.

Concurrent use of choline magnesium salicylate and warfarin (Coumadin), a blood thinner, may cause excessive bleeding as choline magnesium salicylate enhances the effect of warfarin. It is therefore important to reduce the dosage of warfarin.

NSAIDs may reduce the blood pressure-lowering effects of drugs that are given to reduce blood pressure. This may occur because prostaglandins play a role in the regulation of blood pressure.

Persons who have more than three alcoholic beverages per day may be at increased risk of developing stomach ulcers when taking choline magnesium salicylate or other NSAIDs.

PREGNANCY: There are no adequate studies in pregnant women. Choline magnesium salicylate should only be given if the potential benefits outweigh the potential risks to the fetus.

Medically Reviewed by a Doctor on 8/27/2014

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Pill Finder Tool

Need help identifying pills and medications?
Use the pill identifier tool on RxList.

Back to Medications Index