For rheumatoid arthritis, osteoarthritis, other severe arthritis, and acute painful joints, the recommended starting dosage is 1500 mg given twice a day. The recommended dose range is 1000 to 3000 mg given every 8 to 12 hours.
For mild to moderate pain or fever, the usual dosage is 1000 mg to 1500 mg every 12 hours.
DRUG INTERACTIONS: Choline magnesium salicylate, as other salicylates, should not be given within six weeks of influenza virus vaccine as this can increase risk of Reye's syndrome (a serious, often fatal disease that causes numerous detrimental effects to many organs, especially the brain and liver) due to unknown mechanisms.
When choline magnesium salicylate is used in combination with methotrexate (Rheumatrex, Trexall), an antimetabolite, the blood levels of methotrexate may increase, presumably because the elimination of methotrexate from the body is reduced. This may lead to more methotrexate-related side effects.
Concurrent use of choline magnesium salicylate and warfarin (Coumadin), a blood thinner, may cause excessive bleeding as choline magnesium salicylate enhances the effect of warfarin. It is therefore important to reduce the dosage of warfarin.
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