choline magnesium salicylate, Trilisate

  • Pharmacy Author:
    Annette (Gbemudu) Ogbru, PharmD, MBA

    Dr. Gbemudu received her B.S. in Biochemistry from Nova Southeastern University, her PharmD degree from University of Maryland, and MBA degree from University of Baltimore. She completed a one year post-doctoral fellowship with Rutgers University and Bristol Myers Squibb.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

Symptoms of Rheumatoid Arthritis

DOSING:

For rheumatoid arthritis, osteoarthritis, other severe arthritis, and acute painful joints, the recommended starting dosage is 1500 mg given twice a day. The recommended dose range is 1000 to 3000 mg given every 8 to 12 hours.

For mild to moderate pain or fever, the usual dosage is 1000 mg to 1500 mg every 12 hours.

It should be taken with food to prevent an upset stomach. This drug should not be used in children or teens with chickenpox or flu symptoms.

DRUG INTERACTIONS: Choline magnesium salicylate, as other salicylates, should not be given within six weeks of influenza virus vaccine as this can increase risk of Reye's syndrome (a serious, often fatal disease that causes numerous detrimental effects to many organs, especially the brain and liver) due to unknown mechanisms.

When choline magnesium salicylate is used in combination with methotrexate (Rheumatrex, Trexall), an antimetabolite, the blood levels of methotrexate may increase, presumably because the elimination of methotrexate from the body is reduced. This may lead to more methotrexate-related side effects.

Concurrent use of choline magnesium salicylate and warfarin (Coumadin), a blood thinner, may cause excessive bleeding as choline magnesium salicylate enhances the effect of warfarin. It is therefore important to reduce the dosage of warfarin.

Medically Reviewed by a Doctor on 8/27/2014

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