choline magnesium salicylate, Trilisate

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GENERIC NAME: choline magnesium salicylate

BRAND NAME: Trilisate (Please Note: This brand name drug is no longer available in the US)

DRUG CLASS AND MECHANISM: Choline magnesium salicylate (or trisalicylate) is a type of nonsteroidal anti-inflammatory drug (NSAID), referred to as a salicylate, which is effective in treating fever, pain, and inflammation in the body. Other drugs within the same class are aspirin, diflunisal (Dolobid) and salsalate (Disalcid). They work by reducing the levels of prostaglandins, chemicals that are responsible for pain, fever, and inflammation. The salicylates block the enzyme that makes prostaglandins (cyclooxygenase), resulting in lower concentrations of prostaglandins. As a consequence, inflammation, pain and fever are reduced.



PREPARATIONS: Tablets: 500, 750, and 1000 mg. Liquid: 500 mg/5 ml.

STORAGE: Choline magnesium salicylate should be stored at controlled room temperature 15 C to 30 C (59 F to 86 F) in a sealed container protected from light and moisture.

PRESCRIBED FOR: Choline magnesium salicylate is used for the rapid relief of mild to moderate pain and fever. Choline magnesium salicylate also is used for the treatment of inflammation and pain due to soft tissue injuries, tendinitis, bursitis, rheumatoid arthritis, osteoarthritis, juvenile arthritis, and other related arthritis conditions.


For rheumatoid arthritis, osteoarthritis, other severe arthritis, and acute painful joints, the recommended starting dosage is 1500 mg given twice a day. The recommended dose range is 1000 to 3000 mg given every 8 to 12 hours.

For mild to moderate pain or fever, the usual dosage is 1000 mg to 1500 mg every 12 hours.

It should be taken with food to prevent an upset stomach. This drug should not be used in children or teens with chickenpox or flu symptoms.

DRUG INTERACTIONS: Choline magnesium salicylate, as other salicylates, should not be given within six weeks of influenza virus vaccine as this can increase risk of Reye's syndrome (a serious, often fatal disease that causes numerous detrimental effects to many organs, especially the brain and liver) due to unknown mechanisms.

When choline magnesium salicylate is used in combination with methotrexate (Rheumatrex, Trexall), an antimetabolite, the blood levels of methotrexate may increase, presumably because the elimination of methotrexate from the body is reduced. This may lead to more methotrexate-related side effects.

Concurrent use of choline magnesium salicylate and warfarin (Coumadin), a blood thinner, may cause excessive bleeding as choline magnesium salicylate enhances the effect of warfarin. It is therefore important to reduce the dosage of warfarin.

NSAIDs may reduce the blood pressure-lowering effects of drugs that are given to reduce blood pressure. This may occur because prostaglandins play a role in the regulation of blood pressure.

Persons who have more than three alcoholic beverages per day may be at increased risk of developing stomach ulcers when taking choline magnesium salicylate or other NSAIDs.

Medically Reviewed by a Doctor on 8/27/2014

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