chlorthalidone, Thalitone (Hygroton discontinued brand in USA) (cont.)

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Edema is treated with 50 to 100 mg daily or 100 mg every other day and the maximum dose is 200 mg daily.

Heart failure is treated with 12.5 to 100 mg daily.

DRUG INTERACTIONS: Chlorthalidone can lower blood potassium and magnesium levels because both potassium and magnesium are lost in the urine. This is especially true in patients who are also taking another class of diuretics, called loop diuretics which includes furosemide (Lasix), bumetanide (Bumex), and torsemide (Demadex). Low potassium and magnesium levels can lead to abnormal heart rhythms, especially in patients taking digoxin (Lanoxin).

Chlorthalidone reduces the kidney's ability to eliminate lithium (Eskalith, Lithobid) in the urine. As a result, patients taking chlorthalidone at the same time as drugs containing lithium may develop high levels of lithium and lithium toxicity.

Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Motrin), naproxen (Naprosyn), and nabumetone (Relafen) can reduce the effectiveness of chlorthalidone though the reason for this is not clear. Blood sugar levels can be elevated by thiazide diuretics. Patients with diabetes may need to adjust the doses of of medications they are taking for treating diabetes.

PREGNANCY: Thiazide diuretics including chlorthalidone cross the placenta and can cause jaundice in the fetus or newborn. Therefore, chlorthalidone should not be used during pregnancy unless absolutely necessary.

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