chlorthalidone, Thalitone (Hygroton discontinued brand in USA)

  • Medical Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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GENERIC AVAILABLE: Yes

PRESCRIPTION: Yes

PREPARATIONS: Tablets: 15, 25, 50, and 100 mg.

STORAGE: Tablets should be stored at room temperature, 15 C - 30 C (59 F - 86 F).

DOSING: The optimal dose of chlorthalidone varies greatly from patient to patient.

For high blood pressure the recommended dose range is 25 to 100 mg daily. Most patients receive 12.5 to 25 mg daily.

Edema is treated with 50 to 100 mg daily or 100 mg every other day and the maximum dose is 200 mg daily.

Heart failure is treated with 12.5 to 100 mg daily.

DRUG INTERACTIONS: Chlorthalidone can lower blood potassium and magnesium levels because both potassium and magnesium are lost in the urine. This is especially true in patients who are also taking another class of diuretics, called loop diuretics which includes furosemide (Lasix), bumetanide (Bumex), and torsemide (Demadex). Low potassium and magnesium levels can lead to abnormal heart rhythms, especially in patients taking digoxin (Lanoxin).

Chlorthalidone reduces the kidney's ability to eliminate lithium (Eskalith, Lithobid) in the urine. As a result, patients taking chlorthalidone at the same time as drugs containing lithium may develop high levels of lithium and lithium toxicity.

Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Motrin), naproxen (Naprosyn), and nabumetone (Relafen) can reduce the effectiveness of chlorthalidone though the reason for this is not clear. Blood sugar levels can be elevated by thiazide diuretics. Patients with diabetes may need to adjust the doses of of medications they are taking for treating diabetes.

Medically Reviewed by a Doctor on 1/27/2015

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