chlorthalidone, Thalitone (Hygroton discontinued brand in USA)

  • Medical Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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GENERIC NAME: chlorthalidone

BRAND NAME: Thalitone

DISCONTINUED BRAND: Hygroton (discontinued in U.S.A.)

DRUG CLASS AND MECHANISM: Chlorthalidone is a diuretic (water pill). It works by reducing the kidneys' ability to hold on to salt and water and increasing the kidneys' production of urine (diuresis). It is used to eliminate excess salt and water from the body and to treat high blood pressure. Chlorthalidone is closely related chemically to hydrochlorothiazide. (Both are "thiazide" diuretics.). It was approved by the FDA in 1960.

PRESCRIBED FOR: Chlorthalidone is used in the treatment of high blood pressure, congestive heart failure, and edema (fluid retention).

SIDE EFFECTS: Chlorthalidone generally is well tolerated.

  • Low blood levels of potassium, sodium, and magnesium due to increased excretion via urine.
  • High blood calcium levels also can occur, especially in persons who are taking calcium supplements.
  • Thiazide diuretics such as chlorthalidone increase the levels of uric acid in the blood, but gout (which is caused by high levels of uric acid) rarely occurs.
  • Chlorthalidone can cause high blood sugars in patients with diabetes.

Other important side effects include:

Medically Reviewed by a Doctor on 1/27/2015

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