All sulfonylureas can lower blood sugar (glucose levels) to the point of causing symptoms and signs (hypoglycemia). Therefore, these agents must be used carefully with patients who have other physical or medical factors that may lower their blood glucose. These factors include:
Sulfonylureas may cause:
- weight gain,
- sun sensitivity (skin rash), and
- allergic-type skin-reactions such as itching and hives..
Rarely, blood disorders occur; for example, low white cell counts or low red cell counts.
GENERIC AVAILABLE: Yes
PREPARATIONS: Tablets: 100 or 250 mg
STORAGE: Chlorpropamide should be stored at room temperature, 15 C to 30 C (59 F to 86 F) in an air-tight container.
- The recommended dose for middle-aged stable diabetic patients is 250 mg daily. The dose may be increased or decreased by 50 to 125 mg daily at 3 to 5 day intervals.
- Older patients are started at 100 to 125 mg daily. The usual dose maintenance dose is 100 to 500 mg daily.
- Chlorpropamide should be taken 30 minutes before meals.
Drugs that may interact with chlorpropamide and increase the risk of hypoglycemia include:
- Blood thinning agents warfarin (Coumadin, Jantoven)
- chloramphenicol (Ak-Chlor)
- clofibrate (Atromid)
- MAO inhibitors including tranylcypromine (Parnate)
- Nonsteroidal anti-inflammatory drugs including ibuprofen (Motrin), and aspirin
- Sulfonamides including sulfamethoxazole (Gantanol), phenylbutazone (Azolid), and drugs that make urine more acidic including ammonium chloride.
Quick GuideDiabetes: Best and Worst Meals for Diabetes-Savvy Dining
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