chlorpropamide, Diabinese

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Charles Patrick Davis, MD, PhD
    Charles Patrick Davis, MD, PhD

    Charles Patrick Davis, MD, PhD

    Dr. Charles "Pat" Davis, MD, PhD, is a board certified Emergency Medicine doctor who currently practices as a consultant and staff member for hospitals. He has a PhD in Microbiology (UT at Austin), and the MD (Univ. Texas Medical Branch, Galveston). He is a Clinical Professor (retired) in the Division of Emergency Medicine, UT Health Science Center at San Antonio, and has been the Chief of Emergency Medicine at UT Medical Branch and at UTHSCSA with over 250 publications.

Type 2 Diabetes Warning Signs

All sulfonylureas can lower blood sugar (glucose levels) to the point of causing symptoms and signs (hypoglycemia). Therefore, these agents must be used carefully with patients who have other physical or medical factors that may lower their blood glucose. These factors include:

Sulfonylureas may cause:

Rarely, blood disorders occur; for example, low white cell counts or low red cell counts.

Fluid retention and swelling of the body due to jaundice, hepatitis, or a low blood sodium concentrate occur rarely.



PREPARATIONS: Tablets: 100 or 250 mg

STORAGE: Chlorpropamide should be stored at room temperature, 15 C to 30 C (59 F to 86 F) in an air-tight container.


  • The recommended dose for middle-aged stable diabetic patients is 250 mg daily. The dose may be increased or decreased by 50 to 125 mg daily at 3 to 5 day intervals.
  • Older patients are started at 100 to 125 mg daily. The usual dose maintenance dose is 100 to 500 mg daily.
  • Chlorpropamide should be taken 30 minutes before meals.


Drugs that may interact with chlorpropamide and increase the risk of hypoglycemia include:

Medically Reviewed by a Doctor on 12/19/2014

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