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- What is chlorpropamide, and how does it work (mechanism of action)?
- What brand names are available for chlorpropamide?
- Is chlorpropamide available as a generic drug?
- Do I need a prescription for chlorpropamide?
- What are the side effects of chlorpropamide?
- What is the dosage for chlorpropamide?
- Which drugs or supplements interact with chlorpropamide?
- Is chlorpropamide safe to take if I'm pregnant or breastfeeding?
- What else should I know about chlorpropamide?
What is the dosage for chlorpropamide?
- The recommended dose for middle-aged stable diabetic patients is 250 mg daily. The dose may be increased or decreased by 50 to 125 mg daily at 3 to 5 day intervals.
- Older patients are started at 100 to 125 mg daily. The usual dose maintenance dose is 100 to 500 mg daily.
- Chlorpropamide should be taken 30 minutes before meals.
Which drugs or supplements interact with chlorpropamide?
Drugs that may interact with chlorpropamide and increase the risk of hypoglycemia include:
- Blood thinning agents warfarin (Coumadin, Jantoven)
- chloramphenicol (Ak-Chlor)
- clofibrate (Atromid)
- MAO inhibitors including tranylcypromine (Parnate)
- Nonsteroidal anti-inflammatory drugs including ibuprofen (Motrin), and aspirin
- Sulfonamides including sulfamethoxazole (Gantanol), phenylbutazone (Azolid), and drugs that make urine more acidic including ammonium chloride.
AAlcohol may interact with chlorpropamide, to cause moderate to severe facial flushing (increased flow of blood to the face) and an increase in facial temperature.
Beta-blockers may lower or increase glucose levels when used alone. When used with sulfonylureas, beta-blocking drugs may interfere with glucose lowering by the sulfonylureas. In addition, beta-blockers can blunt some of the body's protective responses to hypoglycemia, for example, increased heart rate, thus making it difficult for patients to recognize hypoglycemia. This notwithstanding, beta-blockers have been used successfully in diabetic patients and have been associated with improved survival in diabetics with high blood pressure.
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