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- What is chlorpropamide, and how does it work (mechanism of action)?
- What brand names are available for chlorpropamide?
- Is chlorpropamide available as a generic drug?
- Do I need a prescription for chlorpropamide?
- What are the side effects of chlorpropamide?
- What is the dosage for chlorpropamide?
- Which drugs or supplements interact with chlorpropamide?
- Is chlorpropamide safe to take if I'm pregnant or breastfeeding?
- What else should I know about chlorpropamide?
What is chlorpropamide, and how does it work (mechanism of action)?
Chlorpropamide is an oral blood sugar-lowering drug in a class of medications for diabetes treatment called sulfonylureas. It is one of the first four sulfonylureas to be used to manage type II diabetes and it is commonly referred to as a first generation sulfonylurea. The second generation sulfonylureas are glipizide (Glucotrol, Glucotrol XL), glyburide (Micronase), and glimepiride (Amaryl). The primary difference between the first and second generation sulfonylureas is in the way they are eliminated from the body. As a result, second generation sulfonylureas usually are taken less frequently each day than first generation sulfonylureas and generally are preferred when there is poor function of the kidneys. The second generation sulfonylureas were first used in the United States in 1984. The FDA approved chlorpropamide in October 1958.
Approximately 90% of patients with diabetes have type II diabetes, formerly called non-insulin-dependent diabetes mellitus. Type II diabetes usually occurs in adults and is associated with obesity and a strong family history of diabetes. The inability to control blood glucose in type II diabetes is caused by reduced insulin release by the pancreas as well as decreased removal of glucose from the blood by the body's cells.
What brand names are available for chlorpropamide?
Is chlorpropamide available as a generic drug?
GENERIC AVAILABLE: Yes
Do I need a prescription for chlorpropamide?
What are the side effects of chlorpropamide?
Chlorpropamide has similar side effects as other sulfonylureas.
The most common side effects of sulfonylureas are:
The above symptoms usually are avoided if the drug is ingested with a meal.
Hypoglycemia may occur during sulfonylurea therapy. Symptoms and signs include:
- heart palpitations,
- numbness around the mouth,
- tingling of the fingers,
- muscle weakness,
- blurred vision,
- sensation of cold,
- excessive yawning,
- confusion, or
- loss of consciousness.
All sulfonylureas can lower blood sugar (glucose levels) to the point of causing symptoms and signs (hypoglycemia). Therefore, these agents must be used carefully with patients who have other physical or medical factors that may lower their blood glucose. These factors include:
Sulfonylureas may cause:
- weight gain,
- sun sensitivity (skin rash), and
- allergic-type skin-reactions such as itching and hives..
Rarely, blood disorders occur; for example, low white cell counts or low red cell counts.
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