chlorpropamide, Diabinese

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GENERIC NAME: chlorpropamide

BRAND NAME: Diabinese

DRUG CLASS AND MECHANISM: Chlorpropamide is an oral blood sugar-lowering drug in a class of medications for diabetes treatment called sulfonylureas. It is one of the first four sulfonylureas to be used to manage type II diabetes and it is commonly referred to as a first generation sulfonylurea. The second generation sulfonylureas are glipizide (Glucotrol, Glucotrol XL), glyburide (Micronase), and glimepiride (Amaryl). The primary difference between the first and second generation sulfonylureas is in the way they are eliminated from the body. As a result, second generation sulfonylureas usually are taken less frequently each day than first generation sulfonylureas and generally are preferred when there is poor function of the kidneys. The second generation sulfonylureas were first used in the United States in 1984. The FDA approved chlorpropamide in October 1958.

All sulfonylureas lower blood sugar (glucose) by increasing the release of insulin from the pancreas. (Insulin is the hormone that lowers the blood sugar level.)

Medically Reviewed by a Doctor on 12/19/2014



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