chlorpheniramine, pseudoephedrine, Deconamine (Discontinued)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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What is chlorpheniramine, pseudoephedrine, and how does it work (mechanism of action)?

Deconamine was a brand name medication that contains two different drugs, an antihistamine (chlorpheniramine) and a decongestant (pseudoephedrine). The antihistamine effects of chlorpheniramine account for its effect of reducing allergy symptoms. The decongestant action of pseudoephedrine is a result of blood vessel constriction in the nasal air passages, such as in the nose or sinuses. Brand name and generic formulations of combination products containing only chlorpheniramine and pseudoephedrine have been discontinued in the U. S., most likely due to the regulation of pseudoephedrine distribution.

Is chlorpheniramine, pseudoephedrine available as a generic drug?

GENERIC AVAILABLE: No

Do I need a prescription for chlorpheniramine, pseudoephedrine?

No

What are the side effects of chlorpheniramine, pseudoephedrine?

Side effects of antihistamines include:

Other important side effects of pseudoephedrine include stimulation of the nervous system leading to:

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What is the dosage for chlorpheniramine, pseudoephedrine?

The combination drug may be taken with or without food. It must be used cautiously in patients with heart (coronary artery) disease and angina, diabetes, lung diseases, especially asthma, glaucoma, and narrowing of the stomach exit (pyloric stenosis).

Which drugs or supplements interact with chlorpheniramine, pseudoephedrine?

The combination drug can cause drowsiness and impaired ability to operate machinery. It contains pseudoephedrine which should not be taken with MAO inhibitors drugs. Caution must be exercised in the administration of this drug to patients with heart or lung disease. The combination drug should not be combined with other drugs containing pseudoephedrine (such as Sudafed) because of increased risk of side effects on the heart and blood vessels. While misuse of the combination drug for the purpose of getting "high" is unfamiliar to the editors, it is a specific warning from the manufacturer that patients be aware of possible "additive" effects of the drug when taken with alcohol and other central nervous depressants (such as sedatives and tranquilizers). This means that when the drug is taken with, for example, alcohol, the effect of the alcohol could be magnified. Conversely, alcohol increases the sedating qualities of Deconamine.

What else should I know about chlorpheniramine, pseudoephedrine?

What preparations of chlorpheniramine, pseudoephedrine are available?

Tablets of 4 mg chlorpheniramine/60 mg pseudoephedrine; chew tabs of 1 mg c/15 mg p; syrup of 2 mg c/30 mg p.

How should I keep chlorpheniramine, pseudoephedrine stored?

Combinations of chlorpheniramine and pseudoephedrine should be stored at room temperature in an air-tight container.

Reference: FDA Prescribing Information

Last Editorial Review: 5/27/2015

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Reviewed on 5/27/2015
References
Reference: FDA Prescribing Information

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