chlorhexidine gluconate oral rinse (Peridex, Periogard, Periochip) (cont.)

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Medical and Pharmacy Editor:

Cases of parotid gland swelling and inflammation of the salivary glands (sialadenitis) have been reported.



PREPARATIONS: Chlorhexidine gluconate is available in a 0.12% concentration as an oral rinse solution. Most commonly it is available in a 16 fluid ounce (473 ml) child-resistant dispensing container.

Other sizes that are available are 0.5 fluid ounce (15 ml) and 4 fluid ounce (118 ml) in a child-resistant dispensing container. A 64 fluid ounce (1893 ml) is available in a pump-dispensing container. It also is available as a 2.5 mg chip.

STORAGE: Chlorhexidine gluconate should be store at room temperature between 15 C to 30 C F (59 F to 86 F).

DOSING AND ADMINISTRATION: Usually the mouth is rinsed with 15 ml (1 Tbsp) of undiluted chlorhexidine twice daily (morning and evening) for 30 seconds after brushing.

Individuals must expectorate the chlorhexidine after rinsing and must not rinse their mouths with water or mouthwashes, brush their teeth, or eat immediately after using chlorhexidine.

DRUG INTERACTIONS: There are no significant drug interactions with chlorhexidine.

PREGNANCY: There are no adequate studies of safety and effectiveness of chlorhexidine in pregnant women.

NURSING MOTHERS: It is not known whether chlorhexidine enters the breast milk or not; therefore, it is best to exercise caution before using it in nursing mothers.


FDA Prescribing Information on Chlorhexidine.

Micromedex Drug Information™

Medically Reviewed by a Doctor on 4/23/2015

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