Additionally, inducers of the CYP 3A4 enzymes may increase the activity of these enzymes and cause blood levels of chlordiazepoxide to decrease.
Examples of CYP 3A4 inducers are:
Chlordiazepoxide has depressant effects on the central nervous system. Medications which have similar activity may increase the risk for drowsiness, respiratory depression, and other CNS depressant effects. Therefore, co-administration with alcohol, kava-kava, other benzodiazepines, and opiates should generally be avoided.
PREGNANCY: Chlordiazepoxide is classified as FDA pregnancy risk category D. Due to the risk of potential harm to the fetus, use of chlordiazepoxide during pregnancy is not recommended.
NURSING MOTHERS: This medication is thought to be excreted into breast milk. Due to the lack of conclusive safety data, use in nursing mothers is not recommended.
REFERENCE: FDA Prescribing Information.
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