chlordiazepoxide (Librium)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

Additionally, inducers of the CYP 3A4 enzymes may increase the activity of these enzymes and cause blood levels of chlordiazepoxide to decrease.

Examples of CYP 3A4 inducers are:

Chlordiazepoxide has depressant effects on the central nervous system. Medications which have similar activity may increase the risk for drowsiness, respiratory depression, and other CNS depressant effects. Therefore, co-administration with alcohol, kava-kava, other benzodiazepines, and opiates should generally be avoided.

PREGNANCY: Chlordiazepoxide is classified as FDA pregnancy risk category D. Due to the risk of potential harm to the fetus, use of chlordiazepoxide during pregnancy is not recommended.

NURSING MOTHERS: This medication is thought to be excreted into breast milk. Due to the lack of conclusive safety data, use in nursing mothers is not recommended.

REFERENCE: FDA Prescribing Information.

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