Serious side effects that have been reported are:
GENERIC AVAILABLE: Yes
PREPARATIONS: Oral capsules: 5, 10, and 25 mg
STORAGE: Capsules should be stored at room temperature, between 20 C to 25 C (68 F to 77 F).
- For the treatment of mild to moderate anxiety disorders or symptoms: 5 to 10 mg by mouth 3-4 times daily.
- For the treatment of severe anxiety disorders or symptoms: 20 to 25 mg by mouth 3-4 times daily.
- For the management of preoperative apprehension and anxiety: 5 to 10 mg by mouth 3-4 times daily on days preceding surgery.
- For the treatment of anxiety symptoms in children = 6 years to adolescents the usual daily recommended dose is 5 mg 2-4 times daily.
- Dosage may be increased to 10 mg per day given in 2-3 divided doses if necessary.
- Chlordiazepoxide is not recommended for use in children below the age of 6 years.
Dosing: Geriatric patients
- The usual recommended dose is 5 mg 2 to 4 times daily.
Chlordiazepoxide is metabolized or broken down by a group of enzymes in the liver known as the cytochrome P450 3A4 enzymes. Drugs which inhibit these enzymes reduce the metabolism of chlordiazepoxide and have the potential for causing side effects.
Examples of CYP3A4 inhibitors are:
- amiodarone (Cordarone)
- Anti-retroviral protease inhibitors (some types of anti-HIV medications)
- fluconazole (Diflucan)
- itraconazole (Sporanox)
- ketoconazole (Nizoral)
- voriconazole (Vfend)
- miconazole (Monistat)
- cimetidine (Tagamet)
- clarithromycin (Biaxin)
Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.
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