chlordiazepoxide (Librium)

  • Pharmacy Author:
    Omudhome Ogbru, PharmD

    Dr. Ogbru received his Doctorate in Pharmacy from the University of the Pacific School of Pharmacy in 1995. He completed a Pharmacy Practice Residency at the University of Arizona/University Medical Center in 1996. He was a Professor of Pharmacy Practice and a Regional Clerkship Coordinator for the University of the Pacific School of Pharmacy from 1996-99.

  • Medical and Pharmacy Editor: Jay W. Marks, MD
    Jay W. Marks, MD

    Jay W. Marks, MD

    Jay W. Marks, MD, is a board-certified internist and gastroenterologist. He graduated from Yale University School of Medicine and trained in internal medicine and gastroenterology at UCLA/Cedars-Sinai Medical Center in Los Angeles.

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Serious side effects that have been reported are:

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Oral capsules: 5, 10, and 25 mg

STORAGE: Capsules should be stored at room temperature, between 20 C to 25 C (68 F to 77 F).

DOSING:

Adults

  • For the treatment of mild to moderate anxiety disorders or symptoms: 5 to 10 mg by mouth 3-4 times daily.
  • For the treatment of severe anxiety disorders or symptoms: 20 to 25 mg by mouth 3-4 times daily.
  • For the management of preoperative apprehension and anxiety: 5 to 10 mg by mouth 3-4 times daily on days preceding surgery.

Dosing: Pediatrics

  • For the treatment of anxiety symptoms in children = 6 years to adolescents the usual daily recommended dose is 5 mg 2-4 times daily.
  • Dosage may be increased to 10 mg per day given in 2-3 divided doses if necessary.
  • Chlordiazepoxide is not recommended for use in children below the age of 6 years.

Dosing: Geriatric patients

  • The usual recommended dose is 5 mg 2 to 4 times daily.

DRUG INTERACTIONS:

Chlordiazepoxide is metabolized or broken down by a group of enzymes in the liver known as the cytochrome P450 3A4 enzymes. Drugs which inhibit these enzymes reduce the metabolism of chlordiazepoxide and have the potential for causing side effects.

Examples of CYP3A4 inhibitors are:

Medically Reviewed by a Doctor on 12/22/2014
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